INVESTIGATION OF APOPTOSIS IN NORMAL AND LEUKEMIC CELLS INDUCED BY X-RAY IRRADIATION

被引：0
|
作者：
Nevoie, A. [1 ]
Pascariu, M. [1 ]
Jitaru, D. [2 ]
Ivanov, I. [2 ,3 ]
Constantinescu, D. [2 ,4 ]
Carasevici, E. [2 ,3 ]
Luchian, T. [1 ]
机构：
[1] Alexandru Ioan Cuza Univ, Fac Phys, Iasi, Romania
[2] Hosp St Spiridon, Lab Immunol & Genet, Iasi, Romania
[3] Univ Med & Pharm Gr T Popa, Iasi, Romania
[4] Inst Publ Hlth, Iasi, Romania
来源：
DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES | 2011年 / 6卷 / 01期
关键词：
Normal mononuclear cell; Leukemia cell line; X-ray; Apoptosis; Dose rate; ACUTE NONLYMPHOBLASTIC LEUKEMIA; MARROW TRANSPLANTATION; 1ST REMISSION; RESPONSES;
D O I：
暂无
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The aim of this work is the stydy of the functional changes of normal and leukemic cells exposed to X radiation. Normal mononuclear cells and two human leukemia cell lines (Jurkat and K562) were used for this study. The cells have been grown in the same medium and same conditions. To irradiate the human cells cultures, different doses were used. The process of programmed cell death, apoptosis, has been analyzed using the flow cytometry technique at 3, 24, 48 and 72 hours from irradiation. After 72 hours after the irradiation, the cells show the characteristic signs of apoptosis.
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页码：259 / 264
页数：6
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