Randomized Controlled Trials in Hereditary Cancer Syndromes

被引：0

作者：

Ramamurthy, Chethan ^{[1
]}

Chertock, Yana ^{[2
]}

Hall, Michael J. ^{[2
]}

机构：

[1] Fox Chase Canc Ctr, Dept Med Oncol, 333 Cottman Ave, Philadelphia, PA 19111 USA

[2] Fox Chase Canc Ctr, Dept Clin Genet, 333 Cottman Ave, Philadelphia, PA 19111 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2017年 / 26卷 / 04期

关键词：

Hereditary cancer syndromes; Clinical trials; HBOC; FAP; Lynch; HNPCC; Germline mutations; FAMILIAL ADENOMATOUS POLYPOSIS; CONTRALATERAL BREAST-CANCER; BRCA2 MUTATION CARRIERS; SELECTIVE CYCLOOXYGENASE-2 INHIBITOR; REDUCING SALPINGO-OOPHORECTOMY; PROSPECTIVE MULTICENTER COHORT; COLORECTAL-CANCER; LYNCH SYNDROME; PROPHYLACTIC MASTECTOMY; PRIMARY CHEMOPREVENTION;

D O I：

10.1016/j.soc.2017.05.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Conducting randomized controlled trials (RCTs) in patients with germline mutations in genes that predispose to adult-onset cancer is hampered by the rarity of these mutations, barriers to their identification, and challenges inherent to randomizing high-risk individuals as part of a clinical trial. Most of the clinically relevant RCTs have been conducted in 3 syndromes in only some of the high-risk genes for which clinical testing is currently available. This article reviews the surgical, screening, and chemoprevention RCTs in each of the syndromes in clinically relevant studies conducted in the past 10 years.

引用

页码：729 / +

页数：23

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