Acanthamoeba keratitis -: Persistent organisms without inflammation after 1 year of topical chlorhexidine

被引：18

作者：

Gooi, Patrick ^{[1
,2
]}

Lee-Wing, Matthew ^{[1
]}

Brownstein, Seymour ^{[1
,2
]}

El-Defrawy, Sherif ^{[1
]}

Jackson, W. Bruce ^{[1
]}

Mintsioulis, George ^{[1
]}

机构：

[1] Univ Ottawa, Inst Eye, Dept Ophthalmol, Ottawa, ON K1H 8L6, Canada

[2] Ottawa Hosp, Dept Pathol, Ottawa, ON, Canada

来源：

CORNEA | 2008年 / 27卷 / 02期

关键词：

Acanthainoeba; corneal infection; chlorhexidine; histopathology; keratitis;

D O I：

10.1097/ICO.0b013e31815b82a2

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To report a non-contact lens wearer with persistent Acanthamoeba organisms in the cornea after being treated with medical therapy that included topical chlorhexidine as 1 agent for 1 year. Methods: A 53-year-old man with Acanthamoeba keratitis was treated with medical therapy for >1 year, followed by a penetrating keratoplasty. Results: Histopathologic examination of the keratoplasty specimen revealed viable-appearing Acanthamoeba cysts and trophozoites within the deep corneal stroma in a focus of corneal scarring. Conclusions: The use of chlorhexidine as 1 agent in the medical management of Acanthamoeba keratitis may not eradicate the organisms.

引用

页码：246 / 248

页数：3

共 19 条

[1] Tear IgA and serum IgG antibodies against Acanthamoeba in patients with Acanthamoeba keratitis [J].

Alizadeh, H ;

Apte, S ;

El-Agha, MSH ;

Li, L ;

Hurt, M ;

Howard, K ;

Cavanagh, HD ;

McCulley, JP ;

Niederkorn, JY .

CORNEA, 2001, 20 (06) :622-627

[2]

Borazjani R N, 2005, Cont Lens Anterior Eye, V28, P169, DOI 10.1016/j.clae.2005.10.001

[3] Delay in diagnosis and outcome of Acanthamoeba keratitis [J].

Claerhout, I ;

Goegebuer, A ;

Van Den Broecke, C ;

Kestelyn, P .

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2004, 242 (08) :648-653

[4]

FICKER L, 1990, Eye (London), V4, P835

[5] Results of a trial of combined propamidine isethionate and neomycin therapy for Acanthamoeba keratitis [J].

Hargrave, SL ;

McCulley, JP ;

Husseini, Z .

OPHTHALMOLOGY, 1999, 106 (05) :952-957

[6] DRUG-RESISTANCE AND ACANTHAMOEBA-KERATITIS - THE QUEST FOR ALTERNATIVE ANTIPROTOZOAL CHEMOTHERAPY [J].

HAY, J ;

KIRKNESS, CM ;

SEAL, DV ;

WRIGHT, P .

EYE, 1994, 8 :555-563

[7] Acanthamoeba keratitis [J].

Illingworth, CD ;

Cook, SD .

SURVEY OF OPHTHALMOLOGY, 1998, 42 (06) :493-508

[8] Epidemiological characteristics of a Chicago-area Acanthamoeba keratitis outbreak [J].

Joslin, Charlotte E. ;

Tu, Elmer Y. ;

McMahon, Timothy T. ;

Passaro, Doug J. ;

Stayner, Leslie T. ;

Sugar, Joel .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2006, 142 (02) :212-217

[9] Treatment of Acanthamoeba keratitis with chlorhexidine [J].

Kosrirukvongs, P ;

Wanachiwanawin, D ;

Vivesvara, GS .

OPHTHALMOLOGY, 1999, 106 (04) :798-802

[10] Recent advances in the treatment of Acanthamoeba keratitis [J].

Kumar, R ;

Lloyd, D .

CLINICAL INFECTIOUS DISEASES, 2002, 35 (04) :434-441

← 1 2 →