Mechanism of Phosgene-Induced Acute Lung Injury and Treatment Strategy

被引：35
作者：
Lu, Qianying [1 ,2 ]
Huang, Siyu [1 ,2 ]
Meng, Xiangyan [1 ,2 ]
Zhang, Jianfeng [1 ,2 ]
Yu, Sifan [1 ,2 ]
Li, Junfeng [1 ,2 ]
Shi, Mingyu [1 ,2 ]
Fan, Haojun [1 ,2 ]
Zhao, Yanmei [1 ,2 ]
机构：
[1] Tianjin Univ, Inst Disaster & Emergency Med, Tianjin 300072, Peoples R China
[2] Tianjin Key Lab Disaster Med Technol, Tianjin 300072, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 20期
关键词：
phosgene; acute lung injury; inflammation; oxidative stress; MSCs; MESENCHYMAL STEM-CELLS; NF-KAPPA-B; BRONCHOALVEOLAR LAVAGE FLUID; ACID PHENETHYL ESTER; HEAT-SHOCK-PROTEIN; UP-REGULATION; NITRIC-OXIDE; NLRP3; INFLAMMASOME; LIPID-PEROXIDATION; CHEMICAL WARFARE;
D O I：
10.3390/ijms222010933
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phosgene (COCl2) was once used as a classic suffocation poison and currently plays an essential role in industrial production. Due to its high toxicity, the problem of poisoning caused by leakage during production, storage, and use cannot be ignored. Phosgene mainly acts on the lungs, causing long-lasting respiratory depression, refractory pulmonary edema, and other related lung injuries, which may cause acute respiratory distress syndrome or even death in severe cases. Due to the high mortality, poor prognosis, and frequent sequelae, targeted therapies for phosgene exposure are needed. However, there is currently no specific antidote for phosgene poisoning. This paper reviews the literature on the mechanism and treatment strategies to explore new ideas for the treatment of phosgene poisoning.
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