Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study

被引：18

作者：

Duan, Hualin ^{[1
]}

Zhang, Rong ^{[2
]}

Chen, Xingying ^{[1
]}

Yu, Genfeng ^{[1
]}

Song, Cheng ^{[1
]}

Jiang, Yuqi ^{[1
]}

He, Yajun ^{[1
]}

Wan, Heng ^{[1
,3
]}

Shen, Jie ^{[1
]}

机构：

[1] Southern Med Univ, Shunde Hosp, Peoples Hosp Shunde Foshan 1, Dept Endocrinol & Metab, Foshan, Peoples R China

[2] Affiliated Hosp Xiangnan Univ, Dept Endocinol & Metab Dis, Chenzhou, Peoples R China

[3] Third Affiliated Hosp Southern Med Univ, Dept Endocrinol, Guangzhou, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

liver steatosis; liver fibrosis; controlled attenuation parameter; liver stiffness measurement; uric acid; NHANES; PROGRESSION; DISEASE;

D O I：

10.3389/fendo.2022.930224

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and objectiveSerum uric acid (UA) is related to many metabolic diseases. However, the association of UA with liver diseases was not very clear. The objective of this study is to clarify the relationship of UA with liver steatosis and fibrosis. MethodsThis is a cross-sectional study of 4364 people of National Health and Nutrition Examination Survey (NHANES) 2017-2018. Liver steatosis and fibrosis were assessed by controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) using Vibration-controlled transient elastography (VCTE). Linear and logistic regressions were performed. ResultsAfter adjusting for potential confounders, UA levels were associated with the prevalence of liver steatosis [OR=2.097 (95%CI: 1.245, 3.534)] and liver fibrosis [OR=2.983 (95%CI: 1.797, 4.952)]. Furthermore, the results were consistent in the subgroup analyses of males and females. ConclusionsUA levels were positively associated with the prevalence of liver steatosis and fibrosis.

引用

页数：9

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