Nuclear Imaging of Neuroendocrine Tumors

被引：12
作者：
Pollard, Janet [1 ]
McNeely, Parren [1 ]
Menda, Yusuf [1 ]
机构：
[1] Univ Iowa Hosp & Clin, Roy J & Lucille A Carver Coll Med, Dept Radiol, 200 Hawkins Dr, Iowa City, IA 52242 USA
来源：
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2020年 / 29卷 / 02期
关键词：
Nuclear imaging; Neuroendocrine tumors; NET; Somatostatin receptor analog; Gallium Ga-68; EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY; ENETS CONSENSUS GUIDELINES; GA-68-DOTATATE PET/CT; LIVER METASTASES; CLINICAL UTILITY; MANAGEMENT; NEOPLASMS; PET/MRI; MIDGUT; DOSIMETRY;
D O I：
10.1016/j.soc.2019.11.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Consensus guidelines acknowledge the role of gallium Ga-68 (Ga-68) 1,4,7,10-tetraazacyclododecane-N,N',N '',N'''-tetraacetic (DOTA) somatostatin receptor (SSTR) positron emission tomography/computed tomography (PET/CT) in management of neuroendocrine tumor (NET) patients. Ga-68-DOTA-SSTR PET/CT demonstrates superior performance to conventional imaging in initial detection, staging, detection of recurrent tumor, and detection of unknown primary in known metastatic disease. Ga-68-DOTA-SSTR PET/CT is low yield for NET detection in the setting of symptoms or elevated biomarkers when conventional imaging is negative, but may still guide management. The role of Ga-68-DOTA-SSTR PET/CT is not established in monitoring response to systemic therapy but may identify progression through detection of new metastases.
引用
收藏
页码：209 / +
页数：14
相关论文
共 57 条
[1]   Midgut neuroendocrine tumours with liver metastases: results of the UKINETS study [J].
Ahmed, A. ;
Turner, G. ;
King, B. ;
Jones, L. ;
Culliford, D. ;
McCance, D. ;
Ardill, J. ;
Johnston, B. T. ;
Poston, G. ;
Rees, M. ;
Buxton-Thomas, M. ;
Caplin, M. ;
Ramage, J. K. .
ENDOCRINE-RELATED CANCER, 2009, 16 (03) :885-894
[2]   Clinical value of 68Ga-DOTATATE-PET/CT compared to stand-alone contrast enhanced CT for the detection of extra-hepatic metastases in patients with neuroendocrine tumours (NET) [J].
Albanus, D. R. ;
Apitzsch, J. ;
Erdem, Z. ;
Erdem, O. ;
Verburg, F. A. ;
Behrendt, F. F. ;
Mottaghy, F. M. ;
Heinzel, A. .
EUROPEAN JOURNAL OF RADIOLOGY, 2015, 84 (10) :1866-1872
[3]   68Ga-DOTATATE PET/CT in the evaluation of patients with neuroendocrine metastatic carcinoma of unknown origin [J].
Alonso, Omar ;
Rodriguez-Taroco, Monica ;
Savio, Eduardo ;
Bentancourt, Cecilia ;
Gambini, Juan P. ;
Engler, Henry .
ANNALS OF NUCLEAR MEDICINE, 2014, 28 (07) :638-645
[4]   Is 68Ga-DOTA-NOC PET/CT indicated in patients with clinical, biochemical or radiological suspicion of neuroendocrine tumour? [J].
Ambrosini, Valentina ;
Campana, Davide ;
Nanni, Cristina ;
Cambioli, Silvia ;
Tomassetti, Paola ;
Rubello, Domenico ;
Fanti, Stefano .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 (08) :1278-1283
[5]   68Ga-DOTA-NOC PET/CT in comparison with CT for the detection of bone metastasis in patients with neuroendocrine tumours [J].
Ambrosini, Valentina ;
Nanni, Cristina ;
Zompatori, Maurizio ;
Campana, Davide ;
Tomassetti, Paola ;
Castellucci, Paolo ;
Allegri, Vincenzo ;
Rubello, Domenico ;
Montini, Giancarlo ;
Franchi, Roberto ;
Fanti, Stefano .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2010, 37 (04) :722-727
[6]  
American College of Radiology, 2018, ACR PRACT PAR PERF G
[7]   Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals? [J].
Antunes, P. ;
Ginj, M. ;
Zhang, H. ;
Waser, B. ;
Baum, R. P. ;
Reubi, J. C. ;
Maecke, H. .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2007, 34 (07) :982-993
[8]   The Impact of Somatostatin Receptor-Directed PET/CT on the Management of Patients with Neuroendocrine Tumor: A Systematic Review and Meta-Analysis [J].
Barrio, Martin ;
Czernin, Johannes ;
Fanti, Stefano ;
Ambrosini, Valentina ;
Binse, Ina ;
Du, Lin ;
Eiber, Matthias ;
Herrmann, Ken ;
Fendler, Wolfgang P. .
JOURNAL OF NUCLEAR MEDICINE, 2017, 58 (05) :756-761
[9]   Simultaneous 68Ga-DOTATOC PET/MRI in Patients With Gastroenteropancreatic Neuroendocrine Tumors Initial Results [J].
Beiderwellen, Karsten J. ;
Poeppel, Thorsten D. ;
Hartung-Knemeyer, Verena ;
Buchbender, Christian ;
Kuehl, Hilmar ;
Bockisch, Andreas ;
Lauenstein, Thomas C. .
INVESTIGATIVE RADIOLOGY, 2013, 48 (05) :273-279
[10]   Assigning Site of Origin in Metastatic Neuroendocrine Neoplasms: A Clinically Significant Application of Diagnostic Immunohistochemistry [J].
Bellizzi, Andrew M. .
ADVANCES IN ANATOMIC PATHOLOGY, 2013, 20 (05) :285-314
123456