Biointerface by Cell Growth on Layered Graphene-Artificial Peroxidase-Protein Nanostructure for In Situ Quantitative Molecular Detection

被引:182
作者
Guo, Chun Xian [1 ]
Zheng, Xin Ting [1 ]
Lu, Zhi Song [1 ]
Lou, Xiong Wen [1 ]
Li, Chang Ming [1 ]
机构
[1] Nanyang Technol Univ, Ctr Adv Bionanosyst, Sch Chem & Biomed Engn, Singapore 637457, Singapore
关键词
FIELD-EFFECT TRANSISTORS; SENSORS; SURFACE; DNA; STABILIZATION; NANOPARTICLES; NANOTUBES; SUBSTRATE; COMPOSITE; MATRIX;
D O I
10.1002/adma.201001699
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A smart multifunctional biointerface with dimensional compatibility and good electrical conductivity is constructed by growing human breast adenocarcinoma cells on layered graphene-artificial peroxidase- extracellular matrix protein and further used to in situ selectively and quantatively detect reactive oxygen species, for the first time discovering that the number of extracellular released hydrogen peroxide molecules is around 10(11) per cell.
引用
收藏
页码:5164 / +
页数:5
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