Biointerface by Cell Growth on Layered Graphene-Artificial Peroxidase-Protein Nanostructure for In Situ Quantitative Molecular Detection

被引：182
作者：
Guo, Chun Xian [1 ]
Zheng, Xin Ting [1 ]
Lu, Zhi Song [1 ]
Lou, Xiong Wen [1 ]
Li, Chang Ming [1 ]
机构：
[1] Nanyang Technol Univ, Ctr Adv Bionanosyst, Sch Chem & Biomed Engn, Singapore 637457, Singapore
来源：
ADVANCED MATERIALS | 2010年 / 22卷 / 45期
关键词：
FIELD-EFFECT TRANSISTORS; SENSORS; SURFACE; DNA; STABILIZATION; NANOPARTICLES; NANOTUBES; SUBSTRATE; COMPOSITE; MATRIX;
D O I：
10.1002/adma.201001699
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A smart multifunctional biointerface with dimensional compatibility and good electrical conductivity is constructed by growing human breast adenocarcinoma cells on layered graphene-artificial peroxidase- extracellular matrix protein and further used to in situ selectively and quantatively detect reactive oxygen species, for the first time discovering that the number of extracellular released hydrogen peroxide molecules is around 10(11) per cell.
引用
收藏
页码：5164 / +
页数：5
相关论文
共 39 条
  • [1] Seamless signal transduction from live cells to an NO sensor via a cell-adhesive sensing matrix
    Asakawa, Hitoshi
    Mochitate, Katsumi
    Haruyama, Tetsuya
    [J]. ANALYTICAL CHEMISTRY, 2008, 80 (05) : 1505 - 1511
  • [2] Synthesis of Large-Area Graphene Layers on Poly-Nickel Substrate by Chemical Vapor Deposition: Wrinkle Formation
    Chae, Seung Jin
    Guenes, Fethullah
    Kim, Ki Kang
    Kim, Eun Sung
    Han, Gang Hee
    Kim, Soo Min
    Shin, Hyeon-Jin
    Yoon, Seon-Mi
    Choi, Jae-Young
    Park, Min Ho
    Yang, Cheol Woong
    Pribat, Didier
    Lee, Young Hee
    [J]. ADVANCED MATERIALS, 2009, 21 (22) : 2328 - +
  • [3] Mechanically strong, electrically conductive, and biocompatible graphene paper
    Chen, Haiqun
    Mueller, Marc B.
    Gilmore, Kerry J.
    Wallace, Gordon G.
    Li, Dan
    [J]. ADVANCED MATERIALS, 2008, 20 (18) : 3557 - +
  • [4] Collins R, 2002, LANCET, V360, P23, DOI 10.1016/S0140-6736(02)09328-5
  • [5] Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species
    Cui, Y
    Wei, QQ
    Park, HK
    Lieber, CM
    [J]. SCIENCE, 2001, 293 (5533) : 1289 - 1292
  • [6] Chronic lymphocytic leukaemia
    Dighiero, G.
    Hamblin, T. J.
    [J]. LANCET, 2008, 371 (9617) : 1017 - 1029
  • [7] A novel approach to observing synergy effects of PHSRN on integrin-RGD binding using intelligent surfaces
    Ebara, Mitsuhiro
    Yamato, Masayuki
    Aoyagi, Takao
    Kikuchi, Akihiko
    Sakai, Kiyotaka
    Okano, Teruo
    [J]. ADVANCED MATERIALS, 2008, 20 (16) : 3034 - 3038
  • [8] NAD+/NADH-Sensitive Quantum Dots: Applications To Probe NAD+-Dependent Enzymes and To Sense the RDX Explosive
    Freeman, Ronit
    Willner, Itamar
    [J]. NANO LETTERS, 2009, 9 (01) : 322 - 326
  • [9] The rise of graphene
    Geim, A. K.
    Novoselov, K. S.
    [J]. NATURE MATERIALS, 2007, 6 (03) : 183 - 191
  • [10] Enzyme-Responsive Nanoparticle Systems
    Ghadiali, James E.
    Stevens, Molly M.
    [J]. ADVANCED MATERIALS, 2008, 20 (22) : 4359 - 4363
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