An Acid-Catalysed Conversion of 2-(4-Quinazolinylamino)benzoic Acid into 2-(2-Aminophenyl)-4(1H)-Quinazolinone

被引：2
|
作者：
Sneddon, Helen F. [1 ]
Lynn, Sean M. [1 ]
机构：
[1] GlaxoSmithKline Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England
来源：
SYNLETT | 2011年 / 04期
关键词：
rearrangement; tandem reaction; nucleophilic aromatic substitution; bicyclic compounds; fused ring systems;
D O I：
10.1055/s-0030-1259540
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An acid-catalysed conversion of N-arylcarboxy-4-quinazolinones into 2-(2-aminoaryl)-4(1H)-quinazolinones has been observed. This reaction allows for a nucleophilic aromatic substitution reaction between aminobenzoic acids and 4-chloroquinazolines to form N-arylcarboxy-4-quinazolinones to be followed in situ by a conversion into 2-(2-aminoaryl)-4(1H)-quinazolinones in a one-pot tandem process.
引用
收藏
页码：573 / 575
页数：3
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