One-pot synthesis of polyfluoroalkylphosphonylated dihydropyridines with a carboxylate function from pyridines, alkyl propiolates, and bis(fluoroalkyl) phosphonates

被引：8

作者：

Arbuzova, Svetlana N. ^{[1
]}

Gusarova, Nina K. ^{[1
]}

Kazantseva, Tatyana I. ^{[1
]}

Verkhoturova, Svetlana I. ^{[1
]}

Albanov, Alexander I. ^{[1
]}

Afonin, Andrei V. ^{[1
]}

Trofimov, Boris A. ^{[1
]}

机构：

[1] Russian Acad, Siberian Branch, AE Favorsky Irkutsk Inst Chem, 1 Favorsky Str, Irkutsk 664033, Russia

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 31期

关键词：

Pyridines; Alkyl propiolates; Regioselective synthesis; Polyfluoroalkylphosphonylated (E)-N-alkoxycarbonylethenyldihydropyridines; MEDICINAL CHEMISTRY; FLUORINE; 1,4-DIHYDROPYRIDINES; DERIVATIVES; ALAMIFOVIR; PLASMA; DRUGS;

D O I：

10.1016/j.tetlet.2016.06.105

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The catalyst- and solvent-free reaction between pyridines, alkyl propiolates, and bis(fluoroalkyl) phosphonates occurs under mild conditions (20-52 degrees C, 1-15 h) to stereo- and regioselectively afford bis (polyfluoroalkoxy)phosphoryl-(E)-N-alkoxycarbonylethenyl- 1,2- or 1,4-dihydropyridines in 65-80% yield depending on the structure of the initial pyridine or fluoroalkylphosphonate and the reaction conditions. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：3515 / 3517

页数：3

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