Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core

被引：40

作者：

Fevig, JM ^{[1
]}

Pinto, DJ ^{[1
]}

Han, Q ^{[1
]}

Quan, ML ^{[1
]}

Pruitt, JR ^{[1
]}

Jacobson, IC ^{[1
]}

Galemmo, RA ^{[1
]}

Wang, SA ^{[1
]}

Orwat, MJ ^{[1
]}

Bostrom, LL ^{[1
]}

Knabb, RM ^{[1
]}

Wong, PC ^{[1
]}

Lam, PYS ^{[1
]}

Wexler, RR ^{[1
]}

机构：

[1] DuPont Pharmaceut Co, Wilmington, DE 19880 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(01)00029-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The selective inhibition of coagulation factor Xa has emerged as an attractive strategy for the discovery of novel antithrombotic agents. Here we describe highly potent benzamidine factor Xa inhibitors based on a vicinally-substituted heterocyclic core. (C) 2001 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：641 / 645

页数：5

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Pinto, DJP ;

Orwat, MJ ;

Wang, SG ;

Fevig, JM ;

Quan, ML ;

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Pruitt, JR ;

Pinto, DJ ;

Estrella, MJ ;

Bostrom, LL ;

Knabb, RM ;

Wong, PC ;

Wright, MR ;

Wexler, RR .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (08) :685-689

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