Current Modalities and Mechanisms Underlying Cardioprotection by Ischemic Conditioning

被引:32
作者
Rosenberg, John H. [1 ]
Werner, John H. [1 ]
Moulton, Michael J. [2 ]
Agrawal, Devendra K. [1 ]
机构
[1] Creighton Univ, Sch Med, Dept Clin & Translat Sci, Peekie Nash Carpenter Endowed Chair Med, CRISS 2 Room 510,2500 Calif Plaza, Omaha, NE 68178 USA
[2] Univ Nebraska Med Ctr, Dept Cardiothorac Surg, Omaha, NE USA
关键词
Ischemia; Ischemic conditioning; Cardiomyocytes; Reperfusion injury; Cardioprotection; Reperfusion injury salvage kinase; Survival activator factor enhancement; ACUTE MYOCARDIAL-INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; RANDOMIZED CONTROLLED-TRIAL; ARTERY-BYPASS SURGERY; REPERFUSION INJURY; CARDIAC-SURGERY; ISCHEMIA/REPERFUSION INJURY; CLINICAL TRANSLATION; MULTICENTER TRIAL; GRAFT-SURGERY;
D O I
10.1007/s12265-018-9813-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Ischemic preconditioning is a process which serves to mitigate reperfusion injury. Preconditioning of the heart can be achieved through natural, pharmacological, and mechanical means. Mechanical preconditioning appears to have the greatest chance of good outcomes while methods employing pharmacologic preconditioning have been largely unsuccessful. Remote ischemic preconditioning achieves a cardioprotective effect by applying cycles of ischemia and reperfusion in a distal limb, stimulating the release of a neurohumoral cardioprotective factor incited by stimulation of afferent neurons. The cardioprotective factor stimulates the reperfusion injury salvage kinase (RISK) and survivor activator factor enhancement (SAFE) signaling cascades in cardiomyocytes which promote cell survival by the expression of anti-apoptotic genes and inhibition of the opening of mitochondrial permeability transition pores. Clinical application of ischemic preconditioning involving targets in the RISK and SAFE signaling appears promising in the treatment of acute myocardial infarction; however, clinical trials have yet to demonstrate additional benefit to current therapy.
引用
收藏
页码:292 / 307
页数:16
相关论文
共 90 条
  • [1] Allen MW, 2015, UNDERSEA HYPERBAR M, V42, P107
  • [2] Effect of hypercholesterolaemia on myocardial function, ischaemia-reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning
    Andreadou, Ioanna
    Iliodromitis, Efstathios K.
    Lazou, Antigone
    Gorbe, Aniko
    Giricz, Zoltan
    Schulz, Rainer
    Ferdinandy, Peter
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2017, 174 (12) : 1555 - 1569
  • [3] Preconditioning the hyperlipidemic myocardium: Fact or fantasy?
    Balakumar, Pitchai
    Babbar, Lalita
    [J]. CELLULAR SIGNALLING, 2012, 24 (03) : 589 - 595
  • [4] Influence of diabetes mellitus on heart failure risk and outcome
    Bauters, Christophe
    Lamblin, Nicolas
    Mc Fadden, Eugene P.
    Van Belle, Eric
    Millaire, Alain
    de Groote, Pascal
    [J]. CARDIOVASCULAR DIABETOLOGY, 2003, 2 (1)
  • [5] Conditioning the whole heart-not just the cardiomyocyte
    Bell, Robert M.
    Yellon, Derek M.
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2012, 53 (01) : 24 - 32
  • [6] Progression in attenuating myocardial reperfusion injury: An overview
    Bernink, F. J. P.
    Timmers, L.
    Beek, A. M.
    Diamant, M.
    Roos, S. T.
    Van Rossum, A. C.
    Appelman, Y.
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2014, 170 (03) : 261 - 269
  • [7] Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing cardiac bypass surgery: a randomised controlled clinical trial
    Candilio, Luciano
    Malik, Abdul
    Ariti, Cono
    Barnard, Matthew
    Di Salvo, Carmelo
    Lawrence, David
    Hayward, Martin
    Yap, John
    Roberts, Neil
    Sheikh, Amir
    Kolvekar, Shyam
    Hausenloy, Derek J.
    Yellon, Derek M.
    [J]. HEART, 2015, 101 (03) : 185 - 192
  • [8] Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery - First clinical application in humans
    Cheung, Michael M. H.
    Kharbanda, Rajesh K.
    Konstantinov, Igor E.
    Shimizu, Mikiko
    Frndova, Helena
    Li, Jia
    Holtby, Helen M.
    Cox, Peter N.
    Smallhorn, Jeffrey F.
    Van Arsdell, Glen S.
    Redington, Andrew N.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (11) : 2277 - 2282
  • [9] The mitochondrial permeability transition pore and its role in cell death
    Crompton, M
    [J]. BIOCHEMICAL JOURNAL, 1999, 341 : 233 - 249
  • [10] Cyclosporine before PCI in Patients with Acute Myocardial Infarction
    Cung, T. -T.
    Morel, O.
    Cayla, G.
    Rioufol, G.
    Garcia-Dorado, D.
    Angoulvant, D.
    Bonnefoy-Cudraz, E.
    Guérin, P.
    Elbaz, M.
    Delarche, N.
    Coste, P.
    Vanzetto, G.
    Metge, M.
    Aupetit, J. -F.
    Jouve, B.
    Motreff, P.
    Tron, C.
    Labeque, J. -N.
    Steg, P. G.
    Cottin, Y.
    Range, G.
    Clerc, J.
    Claeys, M. J.
    Coussement, P.
    Prunier, F.
    Moulin, F.
    Roth, O.
    Belle, L.
    Dubois, P.
    Barragan, P.
    Gilard, M.
    Piot, C.
    Colin, P.
    De Poli, F.
    Morice, M. -C.
    Ider, O.
    Dubois-Rande, J. -L.
    Unterseeh, T.
    Le Breton, H.
    Beard, T.
    Blanchard, D.
    Grollier, G.
    Malquarti, V.
    Staat, P.
    Sudre, A.
    Elmer, E.
    Hansson, M. J.
    Bergerot, C.
    Boussaha, I.
    Jossan, C.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (11) : 1021 - 1031