FeCl3•6H2O-Catalyzed Synthesis of β-Ketothioesters from Chain α-Oxo Ketene Dithioactals

被引：9
|
作者：
Zhao Hui [1 ]
Diao Quanping [1 ]
Yu Haifeng [1 ,2 ]
Li Tiechun [1 ]
Liao Peiqiu [2 ]
Hou Dongyan [1 ]
机构：
[1] Anshan Normal Univ, Sch Chem & Life Sci, Anshan 114007, Peoples R China
[2] Northeast Normal Univ, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Dept Chem, Changchun 130024, Jilin, Peoples R China
来源：
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2017年 / 33卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Iron(M) chloride; Thioester; Ketene dithioacetal; Hydrolysis; Friedel-Crafts alkylation; EFFICIENT SYNTHESIS; THIOL EQUIVALENTS; DITHIOACETALS; INDOLES; ODORLESS; ALKENYLATION; THIOESTERS;
D O I：
10.1007/s40242-017-7082-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A FeCl3 center dot 6H(2)O-catalyzed synthesis of beta-ketothioesters from the hydrolysis reaction of chain alpha-oxoketene dithioacetals was carried out. Subsequently, we explored the FeCl3 center dot 6H(2)O-catalyzed Friedel-Crafts alkylation of the synthesized beta-ketothioesters with alcohols in CH3CN at 25 degrees C, affording the desired alpha-alkylated beta-ketothioesters in excellent yields. Wide scope of the substrates, use of inexpensive reagents, high yields under mild reaction conditions are notable features of these reactions.
引用
收藏
页码：746 / 752
页数：7
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