Serum Levels of S100β, Neuron-Specific Enolase, Glial Fibrillary Acidic Protein in Kidney Transplant Recipients and Donors: A Prospective Cohort Study

被引：2

作者：

Dinc, Bora ^{[1
]}

Yilmaz, Vural Taner ^{[2
]}

Aslan, Mutay ^{[3
]}

Aycan, Ilker Onguc ^{[1
]}

Kiraz, Nihal ^{[4
]}

Kisaoglu, Abdullah ^{[5
]}

Dandin, Ozgur ^{[5
]}

Hadimioglu, Necmiye ^{[1
]}

Ertug, Zeki ^{[1
]}

机构：

[1] Akdeniz Univ, Dept Anesthesiol & Reanimat, Med Fac, Antalya, Turkey

[2] Akdeniz Univ, Dept Internal Med, Div Nephrol, Med Fac, Antalya, Turkey

[3] Akdeniz Univ, Dept Biochem, Med Fac, Antalya, Turkey

[4] Akdeniz Univ, Dept Nursing, Organ Transplantat Clin, Med Fac, Antalya, Turkey

[5] Akdeniz Univ, Dept Gen Surg, Med Fac, Antalya, Turkey

来源：

TRANSPLANTATION PROCEEDINGS | 2021年 / 53卷 / 07期

关键词：

RENAL-FUNCTION; S100B; INFLAMMATION; INJURY;

D O I：

10.1016/j.transproceed.2021.07.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. The aim of this study was to evaluate changes in serum levels of S100 beta, neuron specific enolase, glial fibrillary acidic protein in living donors and recipients after kidney transplantation. Methods. We enrolled 56 patients into the study. Of these, 27 underwent donor nephrectomy (group D), and the remaining 29 underwent kidney transplantation (recipient, group R). Neuromarkers were measured in samples obtained before the procedure, on postoperative day 7, and at 1 month postoperatively. Results. Postoperative kidney functions were impaired in patients who underwent living donor nephrectomy compared with their preoperative levels (P < .001), although no significant difference was observed in their neuromarkers. The postoperative delirium rating scale was also impaired after living donor nephrectomy compared with preoperative levels (P < .05). Postoperative kidney functions were improved (P < .001), and a progressive decrease in neuromarker levels (P < .05) was observed in kidney transplant recipients compared with their preoperative levels. Linear regression analysis showed a significant correlation between neuron-specific enolase, glial fibrillary acidic protein levels and kidney functions in recipients. Conclusion. The present study demonstrated that neuron-specific enolase and glial fibrillary acidic protein levels decrease in kidney transplant recipients and do not change in donors. This result indicated that there is no evidence of neurotoxicity in either recipients and donors in kidney transplantation.

引用

页码：2227 / 2233

页数：7