Alkylation and Aminomethylation of 1,3-Dihydro-2De-Benzimidazole-2-Thione

被引：12

作者：

Bespalov, A. Ya. ^{[1
]}

Gorchakova, T. L. ^{[1
]}

Ivanov, A. Yu. ^{[2
]}

Kuznetsov, M. A. ^{[2
]}

Kuznetsova, L. M. ^{[2
]}

Pankova, A. S. ^{[2
]}

Prokopenko, L. I. ^{[1
]}

Avdontceva, M. S. ^{[3
]}

机构：

[1] Fed Med Biol Agcy Russian Federat, Inst Toxicol, St Petersburg 192019, Russia

[2] St Petersburg State Univ, St Petersburg 198504, Russia

[3] St Petersburg State Univ, Res Ctr Xray Diffract Studies, St Petersburg 198504, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2015年 / 50卷 / 11期

基金：

俄罗斯科学基金会;

关键词：

1,3-dihydro-2.-benzimidazole-2-thione; 2-mercaptobenzimidazole; 2-sulfanylbenzimidazole; alkylation; aminomethylation; BIOLOGICALLY-ACTIVE AGENTS; 2-MERCAPTOBENZIMIDAZOLE DERIVATIVES; PART; SPECTROMETRY; MERCURY(II); WATER; ACID;

D O I：

10.1007/s10593-014-1623-z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylation of 1,3-dihydro-2De-benzimidazole-2-thione (2-mercaptobenzimidazole) with bromoethane and chloroacetic acid derivatives occurrs at the sulfur atom, leading to the corresponding 2-sulfanylbenz-imidazole derivatives. Aminomethylation of 1,3-dihydro-2De-benzimidazole-2-thione with piperidine and 4-methylpiperidine gives reaction products at both nitrogen atoms, while reaction with morpholine gives derivative at only one nitrogen atom, which is in an equilibrium with the starting compound and bis-adduct in DMSO solution.

引用

页码：1547 / 1558

页数：12

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