Irreversible Electroporation: A Novel Image-Guided Cancer Therapy

被引：132

作者：

Lee, Edward W. ^{[1
]}

Thai, Susan ^{[1
]}

Kee, Stephen T. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Div Intervent Radiol,Ronald Regan Med Ctr, Los Angeles, CA 90095 USA

来源：

GUT AND LIVER | 2010年 / 4卷

关键词：

Irreversible electroporation; Apoptosis; Tumor treatment; TISSUE ABLATION; GENE-TRANSFER; APOPTOSIS; LIVER; RADIOFREQUENCY; ELECTRODE;

D O I：

10.5009/gnl.2010.4.S1.S99

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Irreversible electroporation (IRE) is a novel tumor ablation technique using a non-thermal energy to create innumerable permanent nanopores in the cell membrane to disrupt cellular homeostasis. This disruption of cellular homeostasis initiates apoptosis which leads to permanent cell death. In our translational research, we have demonstrated that IRE can be a safe, fast and powerful method of tumor treatment. In this review, we present an overview of IRE ablation including a brief history of IRE, advantages and disadvantages of IRE and clinical and research implications of IRE. (Gut Liver 2010;4(Suppl. 1): S99-104)

引用

页码：S99 / S104

页数：6

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