Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

被引:14
|
作者
Macias, Iratxe [1 ]
Alcorta-Sevillano, Natividad [1 ,2 ]
Infante, Arantza [1 ]
Rodriguez, Clara, I [1 ]
机构
[1] Cruces Univ Hosp, BioCruces Bizkaia Hlth Res Inst, Stem Cells & Cell Therapy Lab, Plaza Cruces S-N, Baracaldo 48903, Spain
[2] Univ Basque Country UPV EHU, Leioa 48940, Spain
关键词
MSCs; bone regeneration; tissue engineering; scaffold; composite; hydrogel; cell therapy; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR DELIVERY; MARROW STROMAL CELLS; MORPHOGENETIC PROTEIN-2; OSTEOGENIC DIFFERENTIATION; EXTRACELLULAR-MATRIX; CALCIUM-PHOSPHATE; IN-VITRO; CONTROLLED-RELEASE; COLLAGEN SPONGE;
D O I
10.3390/ijms22147724
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bone damage leading to bone loss can arise from a wide range of causes, including those intrinsic to individuals such as infections or diseases with metabolic (diabetes), genetic (osteogenesis imperfecta), and/or age-related (osteoporosis) etiology, or extrinsic ones coming from external insults such as trauma or surgery. Although bone tissue has an intrinsic capacity of self-repair, large bone defects often require anabolic treatments targeting bone formation process and/or bone grafts, aiming to restore bone loss. The current bone surrogates used for clinical purposes are autologous, allogeneic, or xenogeneic bone grafts, which although effective imply a number of limitations: the need to remove bone from another location in the case of autologous transplants and the possibility of an immune rejection when using allogeneic or xenogeneic grafts. To overcome these limitations, cutting edge therapies for skeletal regeneration of bone defects are currently under extensive research with promising results; such as those boosting endogenous bone regeneration, by the stimulation of host cells, or the ones driven exogenously with scaffolds, biomolecules, and mesenchymal stem cells as key players of bone healing process.
引用
收藏
页数:26
相关论文
共 50 条
  • [21] Biomimetic Strategies for Bone Repair and Regeneration
    Raucci, Maria G.
    Guarino, Vincenzo
    Ambrosio, Luigi
    JOURNAL OF FUNCTIONAL BIOMATERIALS, 2012, 3 (03): : 688 - 705
  • [22] Tissue engineering strategies for bone regeneration
    Mistry, AS
    Mikos, AG
    REGENERATIVE MEDICINE II: CLINICAL AND PRECLINICAL APPLICATIONS, 2005, 94 : 1 - 22
  • [23] The replication strategy of foamy viruses: At the edge between endogenous and exogenous retroviruses?
    Rethwilm, A
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2001, 17 : S15 - S15
  • [24] Liver support strategies: cutting-edge technologies
    Benjamin Struecker
    Nathanael Raschzok
    Igor M. Sauer
    Nature Reviews Gastroenterology & Hepatology, 2014, 11 : 166 - 176
  • [25] Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy
    Hardy, Rowan S.
    Zhou, Hong
    Seibel, Markus J.
    Cooper, Mark S.
    ENDOCRINE REVIEWS, 2018, 39 (05) : 519 - 548
  • [26] Liver support strategies: cutting-edge technologies
    Struecker, Benjamin
    Raschzok, Nathanael
    Sauer, Igor M.
    NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2014, 11 (03) : 166 - 176
  • [27] THERAPEUTIC STRATEGIES IN PROMOTING PERIPHERAL-NERVE REGENERATION
    HOROWITZ, SH
    MUSCLE & NERVE, 1989, 12 (04) : 314 - 322
  • [28] Spatiotemporal Delivery Strategies for Promoting Musculoskeletal Tissue Regeneration
    Guldberg, Robert E.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2009, 24 (09) : 1507 - 1511
  • [29] Retinal pigment epithelial cells: Endogenous and exogenous contraction promoting factors.
    Grisanti, S
    Guidry, C
    Heimann, K
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1996, 37 (03) : 1790 - 1790
  • [30] Promoting Tumor Accumulation of Anticancer Drugs by Hierarchical Carrying of Exogenous and Endogenous Vehicles
    Yue, Yu-Xin
    Zhang, Zhanzhan
    Wang, Ze-Han
    Ma, Rong
    Chen, Meng-Meng
    Ding, Fei
    Li, Hua-Bin
    Li, Juan-Juan
    Shi, Linqi
    Liu, Yang
    Guo, Dong-Sheng
    SMALL STRUCTURES, 2022, 3 (10):