Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

被引:18
作者
Macias, Iratxe [1 ]
Alcorta-Sevillano, Natividad [1 ,2 ]
Infante, Arantza [1 ]
Rodriguez, Clara, I [1 ]
机构
[1] Cruces Univ Hosp, BioCruces Bizkaia Hlth Res Inst, Stem Cells & Cell Therapy Lab, Plaza Cruces S-N, Baracaldo 48903, Spain
[2] Univ Basque Country UPV EHU, Leioa 48940, Spain
关键词
MSCs; bone regeneration; tissue engineering; scaffold; composite; hydrogel; cell therapy; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR DELIVERY; MARROW STROMAL CELLS; MORPHOGENETIC PROTEIN-2; OSTEOGENIC DIFFERENTIATION; EXTRACELLULAR-MATRIX; CALCIUM-PHOSPHATE; IN-VITRO; CONTROLLED-RELEASE; COLLAGEN SPONGE;
D O I
10.3390/ijms22147724
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bone damage leading to bone loss can arise from a wide range of causes, including those intrinsic to individuals such as infections or diseases with metabolic (diabetes), genetic (osteogenesis imperfecta), and/or age-related (osteoporosis) etiology, or extrinsic ones coming from external insults such as trauma or surgery. Although bone tissue has an intrinsic capacity of self-repair, large bone defects often require anabolic treatments targeting bone formation process and/or bone grafts, aiming to restore bone loss. The current bone surrogates used for clinical purposes are autologous, allogeneic, or xenogeneic bone grafts, which although effective imply a number of limitations: the need to remove bone from another location in the case of autologous transplants and the possibility of an immune rejection when using allogeneic or xenogeneic grafts. To overcome these limitations, cutting edge therapies for skeletal regeneration of bone defects are currently under extensive research with promising results; such as those boosting endogenous bone regeneration, by the stimulation of host cells, or the ones driven exogenously with scaffolds, biomolecules, and mesenchymal stem cells as key players of bone healing process.
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页数:26
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