The small RNA expression profile of the developing murine urinary and reproductive systems

被引：17

作者：

Aguilar, Ana Laura Gutierrez ^{[1
]}

Piskol, Robert ^{[3
]}

Beitzinger, Michaela ^{[2
]}

Zhu, Jia Yun ^{[1
]}

Kruspe, Dagmar ^{[4
]}

Aszodi, Attila ^{[5
]}

Moser, Markus ^{[5
]}

Englert, Christoph ^{[4
]}

Meister, Gunter ^{[1
,2
]}

机构：

[1] Max Planck Inst Biochem, Lab RNA Biol, D-82152 Martinsried, Germany

[2] Univ Regensburg, D-93053 Regensburg, Germany

[3] Univ Munich, Sect Evolutionary Biol, Dept Biol 2, D-82152 Planegg Martinsried, Germany

[4] Fritz Lipmann Inst eV, Leibniz Inst Age Res, D-07745 Jena, Germany

[5] Max Planck Inst Biochem, Dept Mol Med, D-82152 Martinsried, Germany

来源：

FEBS LETTERS | 2010年 / 584卷 / 21期

关键词：

microRNA; Kidney; Testis; Ovary; Gene silencing; KIDNEY DEVELOPMENT; MICRORNAS; MECHANISMS; MIRNAS; TRANSLATION; REPRESSION; RESOURCE; TARGETS;

D O I：

10.1016/j.febslet.2010.09.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

microRNAs (miRNAs) are small non-coding RNAs with fundamental roles in the regulation of gene expression. miRNAs assemble with Argonaute (Ago) proteins to miRNA-protein complexes (miRNPs), which interact with distinct binding sites on mRNAs and regulate gene expression. Specific miRNAs are key regulators of tissue and organ development and it has been shown in mammals that miRNAs are also involved in the pathogenesis of many diseases including cancer. Here, we have characterized the miRNA expression profile of the developing murine genitourinary system. Using a computational approach, we have identified several miRNAs that are specific for the analyzed tissues or the developmental stage. Our comprehensive miRNA expression atlas of the developing genitourinary system forms an invaluable basis for further functional in vivo studies. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4426 / 4434

页数：9

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