Protective effects of phillyrin against influenza A virus in vivo

被引：54

作者：

Qu, Xin-yan ^{[1
]}

Li, Qing-jun ^{[1
]}

Zhang, Hui-min ^{[2
]}

Zhang, Xiao-juan ^{[1
]}

Shi, Peng-hui ^{[1
]}

Zhang, Xiu-juan ^{[1
]}

Yang, Jing ^{[1
]}

Zhou, Zhe ^{[1
]}

Wang, Sheng-qi ^{[1
]}

机构：

[1] Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Jinan 250355, Shandong, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2016年 / 39卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Phillyrin; Influenza A virus; Mouse; NEURAMINIDASE INHIBITORS; FORSYTHIA-SUSPENSA; INFECTION; H1N1; INFLAMMATION; ANTIOXIDANT; ACTIVATION; RESISTANCE; SECRETION; MEDICINE;

D O I：

10.1007/s12272-016-0775-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Influenza A virus infection represents a great threat to public health. However, owing to side effects and the emergence of resistant virus strains, the use of currently available anti-influenza drugs may be limited. In order to identify novel anti-influenza drugs, we investigated the antiviral effects of phillyrin against influenza A virus infection in vivo. The mean survival time, lung index, viral titers, influenza hemagglutinin (HA) protein and serum cytokines levels, and histopathological changes in lung tissue were examined. Administration of phillyrin at a dose of 20 mg/kg/day for 3 days significantly prolonged the mean survival time, reduced the lung index, decreased the virus titers and interleukin-6 levels, reduced the expression of HA, and attenuated lung tissue damage in mice infected with influenza A virus. Taken together, these data showed that phillyrin had potential protective effects against infection caused by influenza A virus.

引用

页码：998 / 1005

页数：8

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