Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development

被引：313
作者：
Chung, UI
Schipani, E
McMahon, AP
Kronenberg, HM
机构：
[1] Massachusetts Gen Hosp, Endocrine Unit, Boston, MA 02114 USA
[2] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2001年 / 107卷 / 03期
关键词：
D O I：
10.1172/JCI11706
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Vertebrate skeletogenesis requires a well-coordinated transition from chondrogenesis to osteogenesis. Hypertrophic chondrocytes in the growth plate play a pivotal role in this transition. Parathyroid hormone-related peptide (PTHrP), synthesized in the periarticular growth plate, regulates the site at which hypertrophy occurs. By comparing PTH/PTHrP recepfor(-/-)/wild-type (PPR-/-/wild-type) chimeric mice with Ihh(-/-);PPR-/-/wild-type chimeric and Ihh(-/-)/wild-type chimeric mice, we provide in vivo evidence that Indian hedgehog(Ihh), synthesized by prehypertrophic and hypertrophic chondrocytes, regulates the site of hypertrophic differentiation by signaling to the periarticular growth plate and also determines the site of hone collar formation in the adjacent perichondrium. By providing crucial local signals from prehypertrophic and hypertrophic chondrocytes to both chondrocytes and preosteoblasts, Ihh couples chondrogenesis to osteogenesis in endochondral bone development.
引用
收藏
页码：295 / 304
页数：10
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