MicroRNAs in colorectal cancer: Small molecules with big functions

被引：86
作者：
Xuan, Yu [1 ,2 ]
Yang, Huiliang [2 ]
Zhao, Linjie [2 ]
Lau, Wayne Bond [3 ]
Lau, Bonnie [4 ]
Ren, Ning [5 ]
Hu, Yuehong [1 ]
Yi, Tao [1 ]
Zhao, Xia [1 ]
Zhou, Shengtao [1 ]
Wei, Yuquan [2 ]
机构：
[1] Sichuan Univ, West China Second Hosp, Dept Gynecol & Obstet,Minist Educ, Key Lab Obstet & Gynecol & Pediat Dis & Birth Def, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[3] Thomas Jefferson Univ Hosp, Dept Emergency Med, Philadelphia, PA 19107 USA
[4] Stanford Univ, Kaiser Santa Clara Medial Ctr, Dept Surg Emergency Med, Stanford, CA 94305 USA
[5] Sichuan Univ, Coll Biol Sci, Chengdu 610041, Peoples R China
来源：
CANCER LETTERS | 2015年 / 360卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Colorectal cancer; MicroRNA; Tumor suppressor; Oncogene; PROMOTES CELL-PROLIFERATION; BINDING SITE POLYMORPHISM; DNA METHYLATION SIGNATURE; KEY ONCOGENIC COMPONENT; TUMOR-SUPPRESSOR PDCD4; COLON-CANCER; STEM-CELLS; EXPRESSION PROFILE; MIR-17-92; CLUSTER; INDUCED APOPTOSIS;
D O I：
10.1016/j.canlet.2014.11.051
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer (CRC) is the third most lethal malignancy, with pathogenesis intricately dependent upon microRNAs (miRNAs). miRNAs are short, non-protein coding RNAs, targeting the 3'-untranslated regions (3'-UTR) of certain mRNAs. They usually serve as tumor suppressors or oncogenes, and participate in tumor phenotype maintenance. Therefore, miRNAs consequently regulate CRC carcinogenesis and other biological functions, including apoptosis, development, angiogenesis, migration, and proliferation. Due to its differential expression and distinct stability, miRNAs are regarded as molecular biomarkers (for diagnosis/prognosis) and therapeutic targets for CRC. Recently, a remarkable number of miRNAs have been discovered with implications via incompletely understood mechanisms in CRC. As further study of relevant miRNAs continues, it is hopeful that novel miRNA-based therapeutic strategies may be available for CRC patients in the future. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：89 / 105
页数：17
相关论文
共 189 条
  • [1] Role of anti-oncomirs miR-143 and-145 in human colorectal tumors
    Akao, Y.
    Nakagawa, Y.
    Hirata, I.
    Iio, A.
    Itoh, T.
    Kojima, K.
    Nakashima, R.
    Kitade, Y.
    Naoe, T.
    [J]. CANCER GENE THERAPY, 2010, 17 (06) : 398 - 408
  • [2] let-7 microRNA functions as a potential growth suppressor in human colon cancer cells
    Akao, Yukihiro
    Nakagawa, Yoshihito
    Naoe, Tomoki
    [J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (05) : 903 - 906
  • [3] A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
    Akinc, Akin
    Zumbuehl, Andreas
    Goldberg, Michael
    Leshchiner, Elizaveta S.
    Busini, Valentina
    Hossain, Naushad
    Bacallado, Sergio A.
    Nguyen, David N.
    Fuller, Jason
    Alvarez, Rene
    Borodovsky, Anna
    Borland, Todd
    Constien, Rainer
    de Fougerolles, Antonin
    Dorkin, J. Robert
    Jayaprakash, K. Narayanannair
    Jayaraman, Muthusamy
    John, Matthias
    Koteliansky, Victor
    Manoharan, Muthiah
    Nechev, Lubomir
    Qin, June
    Racie, Timothy
    Raitcheva, Denitza
    Rajeev, Kallanthottathil G.
    Sah, Dinah W. Y.
    Soutschek, Juergen
    Toudjarska, Ivanka
    Vornlocher, Hans-Peter
    Zimmermann, Tracy S.
    Langer, Robert
    Anderson, Daniel G.
    [J]. NATURE BIOTECHNOLOGY, 2008, 26 (05) : 561 - 569
  • [4] Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer
    Arndt, Greg M.
    Dossey, Lesley
    Cullen, Lara M.
    Lai, Angela
    Druker, Riki
    Eisbacher, Michael
    Zhang, Chunyan
    Tran, Nham
    Fan, Hongtao
    Retzlaff, Kathy
    Bittner, Anton
    Raponi, Mitch
    [J]. BMC CANCER, 2009, 9 : 374
  • [5] MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    Asangani, I. A.
    Rasheed, S. A. K.
    Nikolova, D. A.
    Leupold, J. H.
    Colburn, N. H.
    Post, S.
    Allgayer, H.
    [J]. ONCOGENE, 2008, 27 (15) : 2128 - 2136
  • [6] MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets
    Baffa, Raffaele
    Fassan, Matteo
    Volinia, Stefano
    O'Hara, Brian
    Liu, Chang-Gong
    Palazzo, Juan P.
    Gardiman, Marina
    Rugge, Massimo
    Gomella, Leonard G.
    Croce, Carlo M.
    Rosenberg, Anne
    [J]. JOURNAL OF PATHOLOGY, 2009, 219 (02) : 214 - 221
  • [7] Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles
    Balaguer, Francesc
    Moreira, Leticia
    Lozano, Juan Jose
    Link, Alexander
    Ramirez, Georgina
    Shen, Yan
    Cuatrecasas, Miriam
    Arnold, Mildred
    Meltzer, Stephen J.
    Syngal, Sapna
    Stoffel, Elena
    Jover, Rodrigo
    Llor, Xavier
    Castells, Antoni
    Boland, C. Richard
    Gironella, Meritxell
    Goel, Ajay
    [J]. CLINICAL CANCER RESEARCH, 2011, 17 (19) : 6239 - 6249
  • [8] Epigenetic Silencing of miR-137 Is an Early Event in Colorectal Carcinogenesis
    Balaguer, Francesc
    Link, Alexander
    Lozano, Juan Jose
    Cuatrecasas, Miriam
    Nagasaka, Takeshi
    Boland, C. Richard
    Goel, Ajay
    [J]. CANCER RESEARCH, 2010, 70 (16) : 6609 - 6618
  • [9] Epigenetic regulation of microRNA expression in colorectal cancer
    Bandres, Eva
    Agirre, Xabier
    Bitarte, Nerea
    Ramirez, Natalia
    Zarate, Ruth
    Roman-Gomez, Jose
    Prosper, Felipe
    Garcia-Foncillas, Jesus
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2009, 125 (11) : 2737 - 2743
  • [10] MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL
    Baraniskin, Alexander
    Birkenkamp-Demtroder, Karin
    Maghnouj, Abdelouahid
    Zoellner, Hannah
    Munding, Johanna
    Klein-Scory, Susanne
    Reinacher-Schick, Anke
    Schwarte-Waldhoff, Irmgard
    Schmiegel, Wolff
    Hahn, Stephan A.
    [J]. CARCINOGENESIS, 2012, 33 (04) : 732 - 739
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