MicroRNAs in colorectal cancer: Small molecules with big functions

被引：86

作者：

Xuan, Yu ^{[1
,2
]}

Yang, Huiliang ^{[2
]}

Zhao, Linjie ^{[2
]}

Lau, Wayne Bond ^{[3
]}

Lau, Bonnie ^{[4
]}

Ren, Ning ^{[5
]}

Hu, Yuehong ^{[1
]}

Yi, Tao ^{[1
]}

Zhao, Xia ^{[1
]}

Zhou, Shengtao ^{[1
]}

Wei, Yuquan ^{[2
]}

机构：

[1] Sichuan Univ, West China Second Hosp, Dept Gynecol & Obstet,Minist Educ, Key Lab Obstet & Gynecol & Pediat Dis & Birth Def, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

[3] Thomas Jefferson Univ Hosp, Dept Emergency Med, Philadelphia, PA 19107 USA

[4] Stanford Univ, Kaiser Santa Clara Medial Ctr, Dept Surg Emergency Med, Stanford, CA 94305 USA

[5] Sichuan Univ, Coll Biol Sci, Chengdu 610041, Peoples R China

来源：

CANCER LETTERS | 2015年 / 360卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Colorectal cancer; MicroRNA; Tumor suppressor; Oncogene; PROMOTES CELL-PROLIFERATION; BINDING SITE POLYMORPHISM; DNA METHYLATION SIGNATURE; KEY ONCOGENIC COMPONENT; TUMOR-SUPPRESSOR PDCD4; COLON-CANCER; STEM-CELLS; EXPRESSION PROFILE; MIR-17-92; CLUSTER; INDUCED APOPTOSIS;

D O I：

10.1016/j.canlet.2014.11.051

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is the third most lethal malignancy, with pathogenesis intricately dependent upon microRNAs (miRNAs). miRNAs are short, non-protein coding RNAs, targeting the 3'-untranslated regions (3'-UTR) of certain mRNAs. They usually serve as tumor suppressors or oncogenes, and participate in tumor phenotype maintenance. Therefore, miRNAs consequently regulate CRC carcinogenesis and other biological functions, including apoptosis, development, angiogenesis, migration, and proliferation. Due to its differential expression and distinct stability, miRNAs are regarded as molecular biomarkers (for diagnosis/prognosis) and therapeutic targets for CRC. Recently, a remarkable number of miRNAs have been discovered with implications via incompletely understood mechanisms in CRC. As further study of relevant miRNAs continues, it is hopeful that novel miRNA-based therapeutic strategies may be available for CRC patients in the future. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：89 / 105

页数：17

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