A case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization

被引：21

作者：

Yamamoto, Hiroyuki ^{[1
,2
]}

Hashimoto, Toni ^{[2
]}

Ohta-Ogo, Keiko ^{[3
]}

Lshibashi-Ueda, Hatuse ^{[3
]}

Imanaka-Yoshida, Kyoko ^{[4
]}

Hiroe, Michiaki ^{[5
]}

Yokochi, Tomoki ^{[6
]}

机构：

[1] Showa Gen Hosp, Cardiovasc Ctr, Dept Cardiol, 8-1-1 Hanakoganei, Kodaira, Tokyo 1878510, Japan

[2] Narita Tomisato Tokushukai Hosp, Dept Cardiovasc Med, Chiba, Japan

[3] Natl Cerebral & Cardiovasc Ctr, Dept Pathol, Suita, Osaka, Japan

[4] Mie Univ, Grad Sch Med, Dept Pathol & Matrix Biol, Tsu, Mie, Japan

[5] Natl Ctr Global & Med, Dept Cardiol, Tokyo, Japan

[6] Chiba Tokushukai Hosp, Dept Clin Res, Chiba, Japan

来源：

CARDIOVASCULAR PATHOLOGY | 2018年 / 37卷

关键词：

Tetanus toxoid immunization; Vaccine-associated myocarditis; Eosinophilic myocarditis; Endomyocardial biopsy; ACUTE MYOPERICARDITIS; VACCINATION; HYPERSENSITIVITY; DIPHTHERIA;

D O I：

10.1016/j.carpath.2018.10.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vaccine-associated myocarditis is an extremely rare, yet potentially lethal disease, which requires early diagnosis and prompt treatment. However, its pathogenesis remains elusive. We report the first case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization, with unique histopathologic findings, characterized by perivascular eosinophilic infiltrates with myocyte necrosis and abundant interstitial lymphocytic infiltrates with myocyte necrosis, separately. A systemic high-dose corticosteroid treatment had a dramatic beneficial effect on hemodynamic instability and resulted in complete recovery. This case highlights the value of endomyocardial biopsy in establishing a definite diagnosis and understanding the pathogenesis of vaccineassociated myocarditis. (C) 2018 The Authors. Published by Elsevier Inc.

引用

页码：54 / 57

页数：4

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