What is the natural ligand of GPR55?

被引：13

作者：

Okuno, Toshiaki ^{[1
]}

Yokomizo, Takehiko ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med, Dept Med Biochem, Higashi Ku, Fukuoka 81285823, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2011年 / 149卷 / 05期

关键词：

GPR55; LPI; natural ligand; lipid; mass spectrometry; CANNABINOID RECEPTOR-LIGAND; ACTIVATED PROTEIN-KINASE; HL-60; CELLS; 2-ARACHIDONOYLGLYCEROL; LYSOPHOSPHATIDYLINOSITOL; ACID; GENERATION; CB1;

D O I：

10.1093/jb/mvr022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GPR55 is a seven transmembrane G protein-coupled receptor and was originally identified as a putative third cannabinoid receptor. Recently, lysophosphatidylinositol (LPI) was reported to be a GPR55 ligand. Stimulation of GPR55 by LPI activates G(12/13) and G(q/11) proteins, induces phosphorylation of the extracellular signal-regulated kinase and increases intracellular calcium concentration. Lysophospholipids are molecularly quite diverse across species and tissues. A recent report showed that the predominant fatty acyl moiety of LPI in rat brain is stearic acid followed by arachidonic acid. The biological activity of arachidonic acid-containing LPI species towards GPR55 was shown to be markedly higher than that of LPI species containing other fatty acyl groups, suggesting that 2-arachidonolyl LPI is the most likely natural ligand of GPR55.

引用

页码：495 / 497

页数：3

共 18 条

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