Invasive disease caused by Haemophilus influenzae type a in Northern Ontario First Nations communities

被引：34
作者：
Kelly, Len [1 ,2 ]
Tsang, Raymond S. W. [3 ]
Morgan, Alanna [1 ,2 ]
Jamieson, Frances B. [4 ,5 ]
Ulanova, Marina [1 ,2 ]
机构：
[1] No Ontario Sch Med, Thunder Bay, ON, Canada
[2] No Ontario Sch Med, Sioux Lookout, ON, Canada
[3] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada
[4] Ontario Agcy Hlth Protect & Promot, Toronto, ON, Canada
[5] Univ Toronto, Fac Med, Dept Lab Med & Pathobiol, Toronto, ON, Canada
来源：
JOURNAL OF MEDICAL MICROBIOLOGY | 2011年 / 60卷 / 03期
关键词：
SEROTYPE-A; EPIDEMIOLOGY; INFECTIONS; VIRULENCE; MANITOBA; STRAINS; CANADA; REPLACEMENT; MENINGITIS; EMERGENCE;
D O I：
10.1099/jmm.0.026914-0
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Seven epidemiologically unrelated cases of invasive Haemophilus influenzae type a (Hia) disease were identified in First Nations communities of Northwestern Ontario, Canada, in 2004-2008. In all cases, Hia was isolated from blood. The clinical presentation in most of the cases was moderately severe and all patients responded to antibiotic therapy. Laboratory analysis of Hia isolates from Northwestern Ontario indicated striking similarities in their phenotypic and genotypic characteristics. The findings are discussed in the context of current epidemiology of invasive Hia disease. Our data along with some published studies by others suggest an increased susceptibility to this infection among North American indigenous populations.
引用
收藏
页码：384 / 390
页数：7
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