Integrity of mixed liposomes contacting a polycation depends on the negatively charged lipid content

被引：46

作者：

Yaroslavov, AA ^{[1
]}

Kiseliova, EA ^{[1
]}

Udalykh, OY ^{[1
]}

Kabanov, VA ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119899, Leninskie Gory, Russia

来源：

LANGMUIR | 1998年 / 14卷 / 18期

关键词：

D O I：

10.1021/la970510f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Interaction of poly(N-ethyl-4-vinylpyridinium bromide) (PEVP) with mixed liquid Liposomes, composed of diphosphatidylglycerol (cardiolipin, CL2-) carrying two anionic phosphodiester headgroups and neutral phosphatidylcholine (PC), was studied. It was shown that integrity of liposomes in complex with PEVP critically depends on the mole fraction of negatively charged CL2- headgroups in the liposomal membrane nu = 2[CL2-]/(2[CL2-] + [PC]). Liposome integrity remains unchanged unless nu exceeds 0.3. At higher CL2- content, PEVP adsorption results in disruption of liposomes and formation of rather strong nonvesicular PEVP-lipid complexes.

引用

页码：5160 / 5163

页数：4

共 12 条

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Yaroslavov, AA
Kiseleva, EA
Udalykh, OY
Kabanov, VA
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Moscow State University, Moscow, 119899, Russia
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YAROSLAVOV, AA
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KABANOV, VA
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Kabanov, VA
Yaroslavov, AA
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[7] Complexes of Negatively Charged Liposomes with Chitosan: Effect of Phase State of the Lipid Bilayer
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Russian Journal of General Chemistry, 2021, 91 : 2079 - 2085
[8] Complexes of Negatively Charged Liposomes with Chitosan: Effect of Phase State of the Lipid Bilayer
Efimova, A. A.
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RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2021, 91 (10) : 2079 - 2085
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