Microwave-assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity

被引：12

作者：

Ashok, Dongamanti ^{[1
]}

Lakshmi, Bommidi Vijaya ^{[1
]}

Ravi, Sidda ^{[1
]}

Ganesh, Arram ^{[1
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2015年 / 80卷 / 03期

关键词：

coumarin; chalcones; Michael addition; microwave irradiation; pyrazolines; ANTIAMEBIC ACTIVITY; CHALCONES; INHIBITORS; ANTIDEPRESSANT; DERIVATIVES;

D O I：

10.2298/JSC140021101A

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of pyrazolines were synthesized by Michael addition of chalcones with hydrazine hydrate in the presence of sodium acetate under conventional heating and microwave irradiation. The structures of the newly synthesized chalcones and pyrazolines were established based on IR, H-1- and C-13-NMR and mass spectral data. All the synthesized compounds were screened for their antimicrobial activity. Some of the compounds showed very good activity compared to standard drugs against all pathogenic bacteria and fungi.

引用

页码：305 / 313

页数：9

共 33 条

[1] Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1, 3-thiazol-2-yl]-1H-pyrazoles
Abdel-Wahab, Bakr F.
Abdel-Aziz, Hatem A.
Ahmed, Essam M.
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (06) : 2632 - 2635
[2] Synthesis, characterization and antiamoebic activity of 1-(thiazolo[4,5-b]quinoxaline-2-yl)-3-phenyl-2-pyrazoline derivatives
Abid, M
Azam, A
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (10) : 2812 - 2816
[3] Synthesis, spectral studies and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3-phenyl-2-pyrazolines
Abid, Mohammad
Bhat, Abdul Roouf
Athar, Fareeda
Azam, Amir
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (01) : 417 - 425
[4] Aggarwal R, 2007, INDIAN J CHEM B, V46, P1332
[5] Synthesis, structural activity relationship and anti-tubercular activity of novel pyrazoline derivatives
Ali, Mohamed Ashraf
Shaharyar, Mohammad
Siddiqui, Anees Ahamed
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (02) : 268 - 275
[6] Ashok D, 2013, INDIAN J HETEROCY CH, V23, P7
[7] Solvent-free microwave-assisted synthesis of E-(1)-(6-benzoyl-3,5-dimethylfuro[3′,2′:4,5]benzo[b]furan-2-yl)-3-(aryl)-2-propen-1-ones and their antibacterial activity
Ashok, D.
Sudershan, K.
Khalilullah, M.
[J]. GREEN CHEMISTRY LETTERS AND REVIEWS, 2012, 5 (02) : 121 - 125
[8] One-pot synthesis of novel spiro 2,3,7,8-tetrahydro-benzo[1,2-b:5,4-b′]-dipyran-4,6-dione and 2,3,8,9-tetrahydro-benzo[1,2-b:4,3-b′]dipyran-4,10-dione derivatives
Ashok, D.
Shravani, D.
[J]. TETRAHEDRON LETTERS, 2008, 49 (50) : 7227 - 7229
[9] Benson H.J., 1990, Microbiological Applications: A Laboratory Manual in General Microbiology
[10] Synthesis and screening of a combinatorial library of naphthalene substituted chalcones:: Inhibitors of leukotriene B4
Deshpande, AM
Argade, NP
Natu, AA
Eckman, J
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (06) : 1237 - 1240

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