Synthesis and Antimicrobial Activity of Novel 2-(aryl)-3[5-(2-oxo-2H-3-chromenyl)-1,3-oxazol-2-yl]-1,3-thiazolan-4-ones

A series of novel 2-(aryl)-3-[5-(2-oxo-2H-3-chromenyl)-1,3-oxazol-2-yl]-1,3-thiazolan-4-ones 4a-j have been synthesized and assayed for their antibacterial activity against Gram-positive bacteria viz. Bacillus subtilis (ATCC 6633), Staphylococcus am-eta (ATCC 6538p), Micrococcus hams (IFC 12708), and Gram-negative bacteria viz. Proteus vulgaris (ATCC 3851), Salmonella typhimurium (ATCC 14028), Escherichia coli (ATCC 25922), and also antifungal activity against Candida albicans (ATCC 10231), Aspergillus fumigants (HIC 6094), Trichophyton rubrum (IFO 9185), and Trichophyton menta-grophytes (IFO 40996). Among the screened compounds, 4d, 4e, 4f, 4g, and 4j exhibited potent inhibitory activity compared with the standard drug at the tested concentrations. The results reveal that, the presence of difluorophenyl in 4f and pipernyl ring in 4j at 2-position of thiazolidine-4-one ring show significant inhibitory activity. The other compounds also showed appreciable activity against the test bacteria and fungi and emerged as potential molecules for further development.