Synthesis and antimycobacterial activity of N-isonicotinoyl-N'-alkylideneferrocenecarbohydrazides

被引：8

作者：

Kulikov, V. N. ^{[1
,2
]}

Nikulin, R. S. ^{[1
,2
]}

Rodionov, A. N. ^{[1
]}

Babusenko, E. S. ^{[2
]}

Babin, V. N. ^{[1
]}

Kovalenko, L. V. ^{[2
]}

Belousov, Yu A. ^{[1
]}

机构：

[1] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28 Ul Vavilova, Moscow 119991, Russia

[2] DI Mendeleev Univ Chem Technol Russia, 9 Miusskaya Pl, Moscow 125047, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2017年 / 66卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

ferrocene; isoniazid; hydrazones; antimicrobial activity; antimycobacterial activity;

D O I：

10.1007/s11172-017-1864-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acylation of ferrocenoylhydrazones with isonicotinoyl chloride hydrochloride in pyridine was used to obtain a number of new N-isonicotinoyl-N'-ylideneferrocenecarbohydrazides in 50-95% yields. The obtained compounds were characterized by NMR and IR spectroscopy and mass-spectrometry. Some of the obtained compounds were found to exhibit pronounced antimycobacterial activity against the Mycobacterium rubrum strain and to have no toxicity with respect to the P. aeruginosa, E. coli, S. aureus, B. subtilis, and C. albicans strains.

引用

页码：1122 / 1125

页数：4

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