Antioxidant and Antibacterial Activity of Sulfonamides Derived from Carvacrol: A Structure-Activity Relationship Study

被引：5
|
作者：
de Oliveira, Aldo S. [1 ]
de Souza, Luiz F. S. [2 ]
Nunes, Ricardo J. [2 ]
Johann, Susana [3 ]
Palomino-Salcedo, David L. [4 ]
Ferreira, Leonardo L. G. [4 ]
Andricopulo, Adriano D. [4 ]
机构：
[1] Fed Univ Santa Catarina UFSC, Dept Exact Sci & Educ, Blumenau, SC, Brazil
[2] Fed Univ Santa Catarina UFSC, Dept Chem, Florianopolis, SC, Brazil
[3] Univ Fed Minas Gerais, UFMG, Dept Microbiol, Belo Horizonte, MG, Brazil
[4] Univ Sao Paulo, Lab Med & Computat Chem, Ctr Res & Innovat Biodivers & Drug Discovery, Inst Phys Sao Carlos, Sao Carlos, SP, Brazil
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2020年 / 20卷 / 03期
基金：
巴西圣保罗研究基金会;
关键词：
Carvacrol; Sulfonamides; Bacterial resistance; S; aureus; E; coli; Antioxidant; ANTIMICROBIAL RESISTANCE; HYDRAZONE;
D O I：
10.2174/1568026619666191127144336
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Background: Bacterial resistance to antibiotics is a growing problem in all countries and has been discussed worldwide. In this sense, the development of new drugs with antibiotic properties is highly desirable in the context of medicinal chemistry. Methodology: In this paper we investigate the antioxidant and antibacterial potential of sulfonamides derived from carvacrol, a small molecule with drug-like properties. Most sulfonamides had antioxidant and antibacterial potential, especially compound S-6, derived from beta-naphthylamine. Results: To understand the possible mechanisms of action involved in biological activity, the experimental results were compared with molecular docking data. Conclusion: This research allows appropriate discussion on the identified structure activity relationships.
引用
收藏
页码：173 / 181
页数：9
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