Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease

被引：15
作者：
Sáez-Valero, J [1 ]
Small, DH [1 ]
机构：
[1] Univ Melbourne, Dept Pathol, Mol Neurobiol Lab, Melbourne, Vic 3010, Australia
来源：
BRAIN RESEARCH | 2001年 / 889卷 / 1-2期
基金：
英国医学研究理事会;
关键词：
glycosylation; acetylcholinesterase; butyrylcholinesterase; Alzheimer's disease; diagnosis; cerebrospinal fluid;
D O I：
10.1016/S0006-8993(00)03144-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Our previous studies have shown that a minor isoform of acetylcholinesterase (AChE) is increased in the cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients. In the present study, the glycosylation of butyrycholinesterase (BuChE) was found to be altered in AD CSF. By combining an analysis of CSF AChE and BuChE glycosylation, it is possible to identify cases of AD with more than 90% sensitivity and specificity. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：247 / 250
页数：4
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