Calix[4]arene-based Multifunctional Ligand as Potent Protein Binding Agent

被引：4
|
作者：
Rostami, Mahshid Esmaielzade [1 ]
Gorji, Banafsheh [1 ]
Zadmard, Reza [2 ]
机构：
[1] Islamic Azad Univ, South Tehran Branch, Dept Chem, Tehran, Iran
[2] CCERCI, Dept Organ Chem, POB 14335-186, Tehran, Iran
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 11期
基金：
美国国家科学基金会;
关键词：
BOVINE SERUM-ALBUMIN; SURFACE RECOGNITION; IN-VITRO; FLUORESCENCE; CALIXARENES; SCAFFOLD;
D O I：
10.1002/jhet.3299
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this work, a new protein binding agent based on multifunctional calix[4]arene CP has been synthesized by a one-pot four-component reaction. Protein binding affinity of designed ligand (CP) was investigated in physiological buffer (pH = 7.4) by fluorescence quenching method and revealed considerable binding affinity between CP and beta-lactoglobulin (BLG). The three-dimensional (3D) fluorescence measurements indicated that binding of CP to BLG did not influence on BLG conformation. Furthermore, the effect of various biologically important metal ions on the binding constant of CP with BLG was investigated.
引用
收藏
页码：2532 / 2537
页数：6
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