Antimicrobial biomaterials based on carbon nanotubes dispersed in poly(lactic-co-glycolic acid)

被引：117
作者：
Aslan, Seyma [1 ]
Loebick, Codruta Zoican [1 ]
Kang, Seoktae [1 ]
Elimelech, Menachem [1 ]
Pfefferle, Lisa D. [1 ]
Van Tassel, Paul R. [1 ]
机构：
[1] Yale Univ, Dept Chem & Environm Engn, New Haven, CT 06520 USA
来源：
NANOSCALE | 2010年 / 2卷 / 09期
基金：
美国国家科学基金会;
关键词：
IN-VITRO ACTIVITY; SURFACE; COATINGS; CONTACT; RELEASE; POLYURETHANES; PERFORMANCE; INFECTION; PATHOGENS; COMPOSITE;
D O I：
10.1039/c0nr00329h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Biomaterials that inactivate microbes are needed to eliminate medical device infections. We investigate here the antimicrobial nature of single-walled carbon nanotubes (SWNTs) incorporated within the biomedical polymer poly(lactic-co-glycolic acid) (PLGA). We find Escherichia coli and Staphylococcus epidermidis viability and metabolic activity to be significantly diminished in the presence of SWNT-PLGA, and to correlate with SWNT length and concentration (<2% by weight). Up to 98% of bacteria die within one hour on SWNT-PLGA versus 15-20% on pure PLGA. Shorter SWNTs are more toxic, possibly due to increased density of open tube ends. This study demonstrates the potential usefulness of SWNT-PLGA as an antimicrobial biomaterial.
引用
收藏
页码：1789 / 1794
页数：6
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