Antimicrobial biomaterials based on carbon nanotubes dispersed in poly(lactic-co-glycolic acid)

被引：117

作者：

Aslan, Seyma ^{[1
]}

Loebick, Codruta Zoican ^{[1
]}

Kang, Seoktae ^{[1
]}

Elimelech, Menachem ^{[1
]}

Pfefferle, Lisa D. ^{[1
]}

Van Tassel, Paul R. ^{[1
]}

机构：

[1] Yale Univ, Dept Chem & Environm Engn, New Haven, CT 06520 USA

来源：

NANOSCALE | 2010年 / 2卷 / 09期

基金：

美国国家科学基金会;

关键词：

IN-VITRO ACTIVITY; SURFACE; COATINGS; CONTACT; RELEASE; POLYURETHANES; PERFORMANCE; INFECTION; PATHOGENS; COMPOSITE;

D O I：

10.1039/c0nr00329h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biomaterials that inactivate microbes are needed to eliminate medical device infections. We investigate here the antimicrobial nature of single-walled carbon nanotubes (SWNTs) incorporated within the biomedical polymer poly(lactic-co-glycolic acid) (PLGA). We find Escherichia coli and Staphylococcus epidermidis viability and metabolic activity to be significantly diminished in the presence of SWNT-PLGA, and to correlate with SWNT length and concentration (<2% by weight). Up to 98% of bacteria die within one hour on SWNT-PLGA versus 15-20% on pure PLGA. Shorter SWNTs are more toxic, possibly due to increased density of open tube ends. This study demonstrates the potential usefulness of SWNT-PLGA as an antimicrobial biomaterial.

引用

页码：1789 / 1794

页数：6

共 55 条

[1] In situ carbon nanotube reinforcements in a plasma-sprayed aluminum oxide nanocomposite coating [J].

Balani, K. ;

Zhang, T. ;

Karakoti, A. ;

Li, W. Z. ;

Seal, S. ;

Agarwal, A. .

ACTA MATERIALIA, 2008, 56 (03) :571-579

[2] Sustained release of antibiotic from polyurethane coated implant materials [J].

Basak, Piyali ;

Adhikari, Basudam ;

Banerjee, Indranil ;

Maiti, Tapas K. .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2009, 20 :213-221

[3] Multi-walled carbon nanotubes induce T lymphocyte apoptosis [J].

Bottini, M ;

Bruckner, S ;

Nika, K ;

Bottini, N ;

Bellucci, S ;

Magrini, A ;

Bergamaschi, A ;

Mustelin, T .

TOXICOLOGY LETTERS, 2006, 160 (02) :121-126

[4] A single-walled-carbon-nanotube filter for removal of viral and bacterial pathogens [J].

Brady-Estevez, Anna S. ;

Kang, Seoktae ;

Elimelech, Menachem .

SMALL, 2008, 4 (04) :481-484

[5] Cyclodextrin-mediated soft cutting of single-walled carbon nanotubes [J].

Chen, J ;

Dyer, MJ ;

Yu, MF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (25) :6201-6202

[6] Synthesis, characterization and in vitro activity of a surface-attached antimicrobial cationic peptide [J].

Chen, Renxun ;

Cole, Nerida ;

Willcox, Mark D. P. ;

Park, Josephine ;

Rasul, Riaz ;

Carter, Elizabeth ;

Kumar, Naresh .

BIOFOULING, 2009, 25 (06) :517-524

[7] Interfacing carbon nanotubes with living cells [J].

Chen, Xing ;

Tam, Un Chong ;

Czlapinski, Jennifer L. ;

Lee, Goo Soo ;

Rabuka, David ;

Zettl, Alex ;

Bertozzi, Carolyn R. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (19) :6292-6293

[8] Low-defect, purified, narrowly (n,m)-dispersed single-walled carbon nanotubes grown from cobalt-incorporated MCM-41 [J].

Chen, Yuan ;

Wei, Li ;

Wang, Bo ;

Lim, Sangyun ;

Ciuparu, Dragos ;

Zheng, Ming ;

Chen, Jia ;

Zoican, Codruta ;

Yang, Yanhui ;

Haller, Gary L. ;

Pfefferle, Lisa D. .

ACS NANO, 2007, 1 (04) :327-336

[9] In Vivo Performance of Melimine as an Antimicrobial Coating for Contact Lenses in Models of CLARE and CLPU [J].

Cole, Nerida ;

Hume, Emma B. H. ;

Vijay, Ajay K. ;

Sankaridurg, Padmaja ;

Kumar, Naresh ;

Willcox, Mark D. P. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (01) :390-395

[10] Cytotoxicity Effects of Different Surfactant Molecules Conjugated to Carbon Nanotubes on Human Astrocytoma Cells [J].

Dong, Lifeng ;

Witkowski, Colette M. ;

Craig, Michael M. ;

Greenwade, Molly M. ;

Joseph, Katherine L. .

NANOSCALE RESEARCH LETTERS, 2009, 4 (12) :1517-1523

← 1 2 3 4 5 6 →