Ultrasound-Guided Percutaneous Laser Ablation of the Thyroid Gland in a Swine Model: Comparison of Ablation Parameters and Ablation Zone Dimensions.

Background To compare laser ablation (LA) zone dimensions at two predetermined energy parameters to cover a theoretical 10 mm zone + 2 mm margin in a thyroid swine model. Methods Approval of the Institutional Animal Care and Use Committee was obtained. After hydrodissection, an ultrasound-guided LA (Elesta Echolaser X4 with Orblaze technology, 1064 nm) was performed in the periphery of the thyroid in 10 swine. Two cohorts were established to ablate a region of 10mm diameter with 2mm margin based on manufacturer's ex vivo data (n= 5 at 3W/1400J and n= 5 at 3W/1800J). The ablation zone was measured on contrast-enhanced computed tomography (CT) and compared to the pathological specimen. Euthanasia was performed 48 hours following ablation. Results All ablations in the 3W/1800J group achieved a diameter of 12 mm +/- 1 mm in three dimensions. In the 3W/1400J group, 1 ablation reached 12 mm +/- 1 mm in 2 dimensions and 4 ablations reached this size in one dimension. Maximum diameter was higher in the 3W/1800J compared to the 3W/1400J group, both on histology (1.46 cm +/- 0.05 vs. 1.1 cm +/- 0.0, p< 0.01) and CT (1.52 cm +/- 0.04 vs. 1.18 cm +/- 0.04, p< 0.01). Similar results were obtained regarding volumes, both on histology (1.12 mL +/- 0.13 vs. 0.57 mL +/- 0.06, p< 0.01) and CT (1.24 mL +/- 0.13 vs. 0.59 mL +/- 0.07, p< 0.01). Histology showed coagulation necrosis and correlated well with CT measurements. Conclusion Optimal parameters to obtain a LA zone of 10 mm with 2 mm margin utilizing a single needle are 3W/1800J.