Licensed pertussis vaccines in the United States History and current state

被引：53
作者：
Klein, Nicola P. [1 ]
机构：
[1] Kaiser Permanente, Vaccine Study Ctr, Oakland, CA 94612 USA
来源：
HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2014年 / 10卷 / 09期
关键词：
acellular; pertussis; vaccines; history; waning; protection; 2 ACELLULAR VACCINES; WHOLE-CELL VACCINE; IMMUNIZED POPULATION; COMBINATION VACCINE; ANTIBODY-RESPONSES; WHOOPING-COUGH; EFFICACY; IMMUNOGENICITY; SAFETY; CHILDREN;
D O I：
10.4161/hv.29576
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The United States switched from whole cell to acellular pertussis vaccines in the 1990s following global concerns with the safety of the whole cell vaccines. Despite high levels of acellular pertussis vaccine coverage, the United States and other countries are experiencing large pertussis outbreaks. The aim of this article is to describe the historical context which led to acellular pertussis vaccine development, focusing on vaccines currently licensed in the US, and to review evidence that waning protection following licensed acellular pertussis vaccines have been significant factors in the widespread reappearance of pertussis.
引用
收藏
页码：2684 / 2690
页数：7
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