Short- and long-term efficacy of single-dose subunit vaccines against Yersinia pestis in mice

被引：90

作者：

Anderson, GW ^{[1
]}

Heath, DG ^{[1
]}

Bolt, CR ^{[1
]}

Welkos, SL ^{[1
]}

Friedlander, AM ^{[1
]}

机构：

[1] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1998年 / 58卷 / 06期

关键词：

D O I：

10.4269/ajtmh.1998.58.793

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A single, subcutaneous, 30-mu g dose of either a combination of the Yersinia pestis proteins F1+V or a F1-V fusion protein adsorbed to the adjuvant aluminum hydroxide, protected Hsd:ND4 mice for one year against pneumonic plague. The recombinant F1+V vaccine provided significant protection as early as day 14 postimmunization. The current Plague Vaccine USP in a single 0.2-ml dose did not provide significant protection in this mouse model. Antibody titers to F1 and V peaked at approximately 5-12 weeks postimmunization and were still detectable one year later. These F1 and V subunit vaccines may offer effective long-term immunity with a reduced dosage schedule when compared with the presently licensed, formalin-killed, whole-cell vaccine.

引用

页码：793 / 799

页数：7

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