Ebola virus disease: a review on epidemiology, symptoms, treatment and pathogenesis

被引：2

作者：

Goeijenbier, M. ^{[1
]}

van Kampen, J. J. A. ^{[1
]}

Reusken, C. B. E. M. ^{[1
]}

Koopmans, M. P. G. ^{[1
,2
]}

van Gorp, E. C. M. ^{[1
]}

机构：

[1] Erasmus MC, Dept Virosci, Rotterdam, Netherlands

[2] Natl Inst Publ Hlth & Environm RIVM Netherlands, Natl Coordinat Ctr Communicable Dis Control CIb, Bilthoven, Netherlands

来源：

NETHERLANDS JOURNAL OF MEDICINE | 2014年 / 72卷 / 09期

关键词：

Ebola virus disease; viral haemorrhagic fever; filovirus; pathogenesis; treatment; VIRAL HEMORRHAGIC FEVERS; ANTIBODY-DEPENDENT ENHANCEMENT; NONHUMAN-PRIMATES; POSTEXPOSURE PROTECTION; WEST-AFRICA; T-705; FAVIPIRAVIR; INFECTED PATIENTS; RNA INTERFERENCE; GUINEA-PIGS; MARBURG;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Currently, West Africa is facing the largest outbreak of Ebola virus disease (EVD) in history. The virus causing this outbreak, the Zaire Ebolavirus (EBOV), belongs to the genus Ebolavirus which together with the genus Marburgvirus forms the family of the Filoviridae. EBOV is one of the most virulent pathogens among the viral haemorrhagic fevers, and case fatality rates up to 90% have been reported. Mortality is the result of multi-organ failure and severe bleeding complications. By 18 September 2014, the WHO reported of 5335 cases (confirmed, suspected and probable) with 2622 deaths, resulting in a case fatality rate of around 50%. This review aims to provide an overview of EVD for clinicians, with the emphasis on pathogenesis, clinical manifestations, and treatment options.

引用

页码：442 / 448

页数：7

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