Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice

被引：30
作者：
Kim, HS
Jang, CG
Park, WK
Oh, KW
Rheu, HM
Cho, DH
Oh, SK
机构：
[1] INST NATL SAFETY RES, SEOUL 122040, SOUTH KOREA
[2] UNIV MISSISSIPPI, MED CTR, DEPT PHARMACOL & TOXICOL, JACKSON, MS 39216 USA
来源：
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1996年 / 27卷 / 02期
关键词：
hyperactivity; conditioned place preference; dopamine receptor supersensitivity; methamphetamine; panax ginseng;
D O I：
10.1016/0306-3623(95)02023-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ginseng total saponin (GTS) inhibited methamphetamine induced hyperactivity and conditioned place preference (CPP). Dopamine (DA) receptor supersensitivity was developed in metham-phetamine-induced CPP mice and it was inhibited by GTS. GTS also inhibited apomorphine induced climbing behavior, showing the antidopaminergic activity of GTS. These results suggest that GTS inhibition of the methamphetamine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by methamphetamine.
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页码：199 / 204
页数：6
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