Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-γ-induced IκB degradation in RAW264.7 macrophages

被引：105
作者：
Murakami, A [1 ]
Matsumoto, K
Koshimizu, K
Ohigashi, H
机构：
[1] Kyoto Univ, Div Food Sci & Biotechnol, Grad Sch Agr, Kyoto 6068502, Japan
[2] Kinki Univ, Dept Biotechnol Sci, Fac Biol Oriented Sci & Technol, Wakayama 6496493, Japan
来源：
CANCER LETTERS | 2003年 / 195卷 / 01期
关键词：
nuclear factor-kappaB; zerumbone; benzylisothiocyanate; genistein; 1'-acetoxycahvicol acetate;
D O I：
10.1016/S0304-3835(03)00058-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Degradation of IkappaB (IKB) is a key step for nuclear factor-kappaB (NF-kappaB)-induced transcription of certain proinflammatory genes, including inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2. We selected seven chemopreventive agents, and examined their effects on combined lipopolysaccharide- and interferon-gamma-induced IKB degradation in RAW264.7 murine macrophages. IKB degradation was notably suppressed by l'-acetoxychavicol acetate (ACA), zerumbone (ZER), and benzylisothiocyanate (BITC), however, not by auraptene (AUR), while the suppressive potencies of nobiletin (NOB), genistein (GEN), and resveratrol (RES) were low, but significant. These results suggest that ACA, ZER, and BITC suppress iNOS/COX-2 gene expression mainly by attenuating IKB degradation, while other chemopreventive agents use alternative pathway(s) to suppress the expression of proinflammatory genes. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：17 / 25
页数：9
相关论文
共 53 条
[31]   Structure-activity relationships of (1′S)-1′-acetoxychavicol acetate, a major constituent of a southeast Asian condiment plant Languas galanga, on the inhibition of tumor-promoter-induced Epstein-Barr virus activation [J].
Murakami, A ;
Toyota, K ;
Ohura, S ;
Koshimizu, K ;
Ohigashi, H .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2000, 48 (05) :1518-1523
[32]  
Murakami A, 1996, ONCOLOGY, V53, P386
[33]   Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis:: the α,β-unsaturated carbonyl group is a prerequisite [J].
Murakami, A ;
Takahashi, D ;
Kinoshita, T ;
Koshimizu, K ;
Kim, HW ;
Yoshihiro, A ;
Nakamura, Y ;
Jiwajinda, S ;
Terao, J ;
Ohigashi, H .
CARCINOGENESIS, 2002, 23 (05) :795-802
[34]   Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation [J].
Murakami, A ;
Takahashi, M ;
Jiwajinda, S ;
Koshimizu, K ;
Ohigashi, H .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1999, 63 (10) :1811-1812
[35]   Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin, possibly through suppression of superoxide generation in leukocytes [J].
Murakami, A ;
Kuki, W ;
Takahashi, Y ;
Yonei, H ;
Nakamura, Y ;
Ohto, Y ;
Ohigashi, H ;
Koshimizu, K .
JAPANESE JOURNAL OF CANCER RESEARCH, 1997, 88 (05) :443-452
[36]   Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats [J].
Murrill, WB ;
Brown, NM ;
Zhang, JX ;
Manzolillo, PA ;
Barnes, S ;
Lamartiniere, CA .
CARCINOGENESIS, 1996, 17 (07) :1451-1457
[37]   Inhibition by 1′-acetoxychavicol acetate of lipopolysaccharide- and interferon-γ-induced nitric oxide production through suppression of inducible nitric oxide synthase gene expression in RAW264 cells [J].
Ohata, T ;
Fukuda, K ;
Murakami, A ;
Ohigashi, H ;
Sugimura, T ;
Wakabayashi, K .
CARCINOGENESIS, 1998, 19 (06) :1007-1012
[38]  
Ohta T, 2002, INT J ONCOL, V21, P37
[39]   Signal-dependent and -independent degradation of free and NF-κB-bound IκBα [J].
Pando, MP ;
Verma, IM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (28) :21278-21286
[40]   Cancer epidemiology in the last century and the next decade [J].
Peto, J .
NATURE, 2001, 411 (6835) :390-395
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