Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-γ-induced IκB degradation in RAW264.7 macrophages

被引：105

作者：

Murakami, A ^{[1
]}

Matsumoto, K

Koshimizu, K

Ohigashi, H

机构：

[1] Kyoto Univ, Div Food Sci & Biotechnol, Grad Sch Agr, Kyoto 6068502, Japan

[2] Kinki Univ, Dept Biotechnol Sci, Fac Biol Oriented Sci & Technol, Wakayama 6496493, Japan

来源：

CANCER LETTERS | 2003年 / 195卷 / 01期

关键词：

nuclear factor-kappaB; zerumbone; benzylisothiocyanate; genistein; 1'-acetoxycahvicol acetate;

D O I：

10.1016/S0304-3835(03)00058-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Degradation of IkappaB (IKB) is a key step for nuclear factor-kappaB (NF-kappaB)-induced transcription of certain proinflammatory genes, including inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2. We selected seven chemopreventive agents, and examined their effects on combined lipopolysaccharide- and interferon-gamma-induced IKB degradation in RAW264.7 murine macrophages. IKB degradation was notably suppressed by l'-acetoxychavicol acetate (ACA), zerumbone (ZER), and benzylisothiocyanate (BITC), however, not by auraptene (AUR), while the suppressive potencies of nobiletin (NOB), genistein (GEN), and resveratrol (RES) were low, but significant. These results suggest that ACA, ZER, and BITC suppress iNOS/COX-2 gene expression mainly by attenuating IKB degradation, while other chemopreventive agents use alternative pathway(s) to suppress the expression of proinflammatory genes. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：17 / 25

页数：9

共 53 条

[1] Role of the peroxisome proliferator-activated receptor-γ (PPAR-γ) and its natural ligand 15-deoxy-Δ12,14-prostaglandin J2 in the regulation of microglial functions [J].

Bernardo, A ;

Levi, G ;

Minghetti, L .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (07) :2215-2223

[2] Cancer chemopreventive activity of resveratrol [J].

Bhat, KPL ;

Pezzuto, JM .

ALCOHOL AND WINE IN HEALTH AND DISEASE, 2002, 957 :210-229

[3] Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages [J].

Chinetti, G ;

Griglio, S ;

Antonucci, M ;

Torra, IP ;

Delerive, P ;

Majd, Z ;

Fruchart, JC ;

Chapman, J ;

Najib, J ;

Staels, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) :25573-25580

[4] Cytokine-activated Jak-2 is involved in inducible nitric oxide synthase expression independent from NF-κB activation in vascular smooth muscle cells [J].

Doi, M ;

Shichiri, M ;

Katsuyama, K ;

Ishimaru, S ;

Hirata, Y .

ATHEROSCLEROSIS, 2002, 160 (01) :123-132

[5] Helicobacter pylori infection and molecular changes in gastric carcinogenesis [J].

Ebert, MPA ;

Schandl, L ;

Malfertheiner, P .

JOURNAL OF GASTROENTEROLOGY, 2002, 37 (Suppl 13) :45-49

[6] NF-κB and rel proteins:: Evolutionarily conserved mediators of immune responses [J].

Ghosh, S ;

May, MJ ;

Kopp, EB .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :225-260

[7] Missing pieces in the NF-κB puzzle [J].

Ghosh, S ;

Karin, M .

CELL, 2002, 109 :S81-S96

[8] Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone [J].

Hecht, SS ;

Kenney, PMJ ;

Wang, MY ;

Trushin, N ;

Upadhyaya, P .

CANCER LETTERS, 2000, 150 (01) :49-56

[9] Phytanic acid, a natural peroxisome proliferator-activated receptor agonist, regulates glucose metabolism in rat primary hepatocytes [J].

Heim, M ;

Johnson, J ;

Boess, F ;

Bendik, I ;

Weber, P ;

Hunziker, W ;

Flühmann, B .

FASEB JOURNAL, 2002, 16 (03) :718-+

[10] Nuclear factor κB is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms [J].

Heiss, E ;

Herhaus, C ;

Klimo, K ;

Bartsch, H ;

Gerhäuser, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (34) :32008-32015

← 1 2 3 4 5 6 →