Phosphane-Catalyzed [3+3] Annulation of C,N-Cyclic Azomethine Imines with Ynones: A Practical Method for Tricyclic Dinitrogen-Fused Heterocycles

被引：51

作者：

Li, Zhen ^{[1
]}

Yu, Hao ^{[1
]}

Liu, Yang ^{[1
]}

Zhou, Leijie ^{[1
]}

Sun, Zhanhu ^{[1
]}

Guo, Hongchao ^{[1
]}

机构：

[1] China Agr Univ, Dept Appl Chem, 2 West Yuanmingyuan Rd, Beijing 100193, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 12期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

annulation; azomethine imines; heterocycles; phosphanes; ynones; ENANTIOSELECTIVE 1,3-DIPOLAR CYCLOADDITION; ASYMMETRIC-SYNTHESIS; CHIRAL PHOSPHINES; FORMAL SYNTHESES; DOMINO REACTION; FACILE ACCESS; DERIVATIVES; REACTIVITY; ALLENOATES; ALDEHYDES;

D O I：

10.1002/adsc.201600223

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A phosphane-catalyzed [3+3] annulation of azomethine imines with ynones has been developed. Under mild reaction conditions, the reaction proceeds smoothly to afford tricyclic dinitrogen-fused heterocyclic compounds in moderate to excellent yields with moderate to excellent stereoselectivies. Using a chiral phosphine as the catalyst, the reaction could work to give the cycloadduct in moderate yield with moderate enantioselectivity.

引用

页码：1880 / 1885

页数：6

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