CD8+ T-cell lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis during methotrexate therapy

被引：12
作者：
Hatachi, Saori [1 ]
Kunitomi, Akane [2 ]
Aozasa, Katsuyuki [3 ]
Yagita, Masato [1 ]
机构：
[1] Kitano Hosp, Div Clin Immunol & Rheumatol, Dept Med, Kita Ku, Osaka 5308480, Japan
[2] Japanese Red Cross Soc Wakayama Med Ctr, Dept Hematol, Wakayama 6408558, Japan
[3] Osaka Univ, Grad Sch Med, Dept Pathol, Suita, Osaka 5650871, Japan
来源：
MODERN RHEUMATOLOGY | 2010年 / 20卷 / 05期
关键词：
CD8 T cells; EBV; LPD; MTX; RA; LYMPHOMA; CANCER; SYSTEM; RISK;
D O I：
10.1007/s10165-010-0300-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 75-year-old woman with rheumatoid arthritis (RA) who was receiving methotrexate (MTX) therapy developed Epstein-Barr virus (EBV)-associated CD8(+) T-cell lymphoproliferative disorder (LPD) and meningoencephalitis. She was successfully treated with acyclovir and corticosteroids plus MTX cessation. T-cell LPD is relatively rare in RA patients receiving MTX. To our knowledge, this is the first report of CD8(+) T-cell LPD with EBV genome occurring during MTX therapy for RA. EBV infection should be carefully monitored to assess severe EBV-associated complications.
引用
收藏
页码：500 / 505
页数：6
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