Clinical and neuroimaging findings in MOGAD-MRI and OCT

被引：48

作者：

Bartels, Frederik ^{[1
,2
,3
]}

Lu, Angelo ^{[2
,3
,4
,5
,6
]}

Oertel, Frederike Cosima ^{[2
,3
,4
,5
,6
]}

Finke, Carsten ^{[1
,3
]}

Paul, Friedemann ^{[1
,2
,3
,4
,5
,6
]}

Chien, Claudia ^{[2
,3
,4
,5
,6
,7
]}

机构：

[1] Charite Univ Med Berlin, Dept Neurol, Berlin, Germany

[2] Freie Univ, Berlin, Germany

[3] Humboldt Univ, Berlin, Germany

[4] Charite Univ Med Berlin, Max Delbruck Ctr Mol Med, Helmholtz Assoc Expt & Clin Res Ctr, Berlin, Germany

[5] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Berlin, Germany

[6] Free Univ Berlin, Humboldt Univ Berlin, Berlin, Germany

[7] Charite Univ Med Berlin, Dept Psychiat & Neurosci, Berlin, Germany

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2021年 / 206卷 / 03期

关键词：

magnetic resonance imaging; myelin oligodendrocyte glycoprotein associated disorders; optical coherence tomography; MYELIN-OLIGODENDROCYTE-GLYCOPROTEIN; OPTICAL COHERENCE TOMOGRAPHY; EXTENSIVE TRANSVERSE MYELITIS; VISUAL-SYSTEM DAMAGE; NEUROMYELITIS-OPTICA; MULTIPLE-SCLEROSIS; SPECTRUM DISORDER; ANTIBODY DISEASE; NEURITIS; CHILDREN;

D O I：

10.1111/cei.13641

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) are rare in both children and adults, and have been recently suggested to be an autoimmune neuroinflammatory group of disorders that are different from aquaporin-4 autoantibody-associated neuromyelitis optica spectrum disorder and from classic multiple sclerosis. In-vivo imaging of the MOGAD patient central nervous system has shown some distinguishing features when evaluating magnetic resonance imaging of the brain, spinal cord and optic nerves, as well as retinal imaging using optical coherence tomography. In this review, we discuss key clinical and neuroimaging characteristics of paediatric and adult MOGAD. We describe how these imaging techniques may be used to study this group of disorders and discuss how image analysis methods have led to recent insights for consideration in future studies.

引用

页码：266 / 281

页数：16

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