Is cognitive impairment associated with antipsychotic dose and anticholinergic equivalent loads in first-episode psychosis?

被引：43

作者：

Ballesteros, Alejandro ^{[1
,2
]}

Sanchez-Torres, Ana M. ^{[2
,3
]}

Lopez-Ilundain, Jose M. ^{[2
,3
]}

Cabrera, Bibiana ^{[4
,5
]}

Lobo, Antonio ^{[6
]}

Gonzalez-Pinto, Ana M. ^{[5
,7
,8
]}

Diaz-Caneja, Covadonga ^{[5
,9
]}

Corripio, Iluminada ^{[5
,10
]}

Vieta, Eduard ^{[5
,11
,12
,13
,14
]}

de la Serna, Elena ^{[5
,15
]}

Bobes, Julio ^{[5
,16
,17
]}

Usall, Judith ^{[5
,18
]}

Contreras, Fernando ^{[5
,19
,20
]}

Lorente-Omenaca, Ruth ^{[2
,3
]}

Mezquida, Gisela ^{[4
,5
]}

Bernardo, Miguel ^{[4
,5
,14
]}

Cuesta, Manuel J. ^{[2
,3
]}

机构：

[1] Estella Mental Hlth Ctr, Direcc Salud Mental, Pamplona, Navarra, Spain

[2] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[3] Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain

[4] Hosp Clin Barcelona, Neurosci Inst, Schizophrenia Unit, Barcelona Clin, Barcelona, Spain

[5] Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain

[6] Univ Zaragoza, Aragon Inst Hlth Res IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain

[7] Univ Hosp, OSI Araba, BIOARABA Hlth Res Inst, Vitoria, Spain

[8] Univ Basque Country, Vitoria, Spain

[9] Univ Complutense, Univ Gregorio Maranon, Sch Med, Hosp Gen,IiSGM,Dept Child & Adolescent Psychiat, Madrid, Spain

[10] UAB, Hosp Santa Creu & Sant Pau, Dept Psychiat, Barcelona, Spain

[11] Hosp Clin Barcelona, Clin Inst Neurosci, Dept Psychiat & Psychol, Catalonia, Spain

[12] August Pi i Sunyer Inst Biomed Res IDIBAPS, Barcelona, Catalonia, Spain

[13] Univ Barcelona, Dept Psychiat & Clin Psychol, Barcelona, Catalonia, Spain

[14] Univ Barcelona, IDIBAPS, Dept Psychiat & Clin Psychobiol, Barcelona, Spain

[15] Univ Barcelona, Hosp Clin Barcelona, Inst Clin Neurosci,Dept Med,2014SGR489, IDIBAPS,Child & Adolescent Psychiat & Psychol Dep, Barcelona, Spain

[16] Univ Oviedo, Psychiat Dept, Oviedo, Spain

[17] INEUROPA, Inst Neurosci Principal Asturias, Oviedo, Spain

[18] Parc Sanitari St Joan Deu, Barcelona, Spain

[19] Bellvitge Univ Hospital, IDIBELL, Psychiat Dept, Lhospitalet De Llobregat, Spain

[20] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain

[21] Univ Valencia, Dept Med, Valencia, Spain

来源：

PSYCHOLOGICAL MEDICINE | 2018年 / 48卷 / 13期

关键词：

Anticholinergic; antipsychotics; cognition; first episode psychosis; premorbid intellectual quotient; SYNDROME SCALE PANSS; NAIVE PATIENTS; DOUBLE-BLIND; 1ST EPISODE; NEUROPSYCHOLOGICAL PERFORMANCE; CHRONIC-SCHIZOPHRENIA; OPEN-LABEL; RISPERIDONE; OLANZAPINE; CONSENSUS;

D O I：

10.1017/S0033291717003774

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background. Cognitive deficits are a core feature of early stages in schizophrenia. However, the extent to which antipsychotic (AP) have a deleterious effect on cognitive performance remains under debate. We aim to investigate whether anticholinergic loadings and dose of AP drugs in first episode of psychosis (FEP) in advanced phase of remission are associated with cognitive impairment and the differences between premorbid intellectual quotient (IQ) subgroups. Methods. Two hundred and sixty-six patients participated. The primary outcomes were cognitive dimensions, dopaminergic/anticholinergic load of AP [in chlorpromazine equivalents (Eq-CPZ) and the Anticholinergic Risk Scale (ARS), respectively]. Results. Impairments in processing speed, verbal memory and global cognition were significantly associated with high Eq-CPZ and verbal impairment with high ARS score. Moreover, this effect was higher in the low IQ subgroup. Conclusions. Clinicians should be aware of the potential cognitive impairment associated with AP in advanced remission FEP, particularly in lower premorbid IQ patients.

引用

页码：2247 / 2256

页数：10

共 83 条

[1] Antipsychotic dose and diminished neural modulation: A multi-site fMRI study
Abbott, C.
Juarez, M.
White, T.
Gollub, R. L.
Pearlson, G. D.
Bustillo, J.
Lauriello, J.
Ho, B.
Bockholt, H. J.
Clark, V. P.
Magnotta, V.
Calhoun, V. D.
[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2011, 35 (02) : 473 - 482
[2] Effects of risperidone on psychometric and cognitive functions in healthy elderly volunteers
Allain, H
Tessier, C
Bentué-Ferrer, D
Tarral, A
Le Breton, S
Gandon, JM
Bouhours, P
[J]. PSYCHOPHARMACOLOGY, 2003, 165 (04) : 419 - 429
[3] Beyond Clinical Remission in First Episode Psychosis: Thoughts on Antipsychotic Maintenance vs. Guided Discontinuation in the Functional Recovery Era
Alvarez-Jimenez, M.
O'Donoghue, B.
Thompson, A.
Gleeson, J. F.
Bendall, S.
Gonzalez-Blanch, C.
Killackey, E.
Wunderink, L.
McGorry, P. D.
[J]. CNS DRUGS, 2016, 30 (05) : 357 - 368
[4] The impact of cognitive reserve in the outcome of first-episode psychoses: 2-year follow-up study
Amoretti, S.
Bernardo, M.
Bonnin, C. M.
Bioque, M.
Cabrera, B.
Mezquida, G.
Sole, B.
Vieta, E.
Torrent, C.
[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2016, 26 (10) : 1638 - 1648
[5] Predictors of early stable symptomatic remission after an exacerbation of schizophrenia: The significance of symptoms, neuropsychological performance and cognitive biases
Andreou, Christina
Roesch-Ely, Daniela
Veckenstedt, Ruth
Bohn, Francesca
Aghotor, Julia
Koether, Ulf
Pfueller, Ute
Moritz, Steffen
[J]. PSYCHIATRY RESEARCH, 2013, 210 (03) : 729 - 734
[6] [Anonymous], 2000, CONTINUOUS PERFORM 2
[7] [Anonymous], 1998, Wechsler adult intelligence scale-IIIUK administration and scoring manual
[8] Negative signs and symptoms secondary to antipsychotics: A double-blind, randomized trial of a single dose of placebo, haloperidol, and risperidone in healthy volunteers
Artaloytia, JF
Arango, C
Lahti, A
Sanz, J
Pascual, A
Cubero, P
Prieto, D
Palomo, T
[J]. AMERICAN JOURNAL OF PSYCHIATRY, 2006, 163 (03) : 488 - 493
[9] Antipsychotic Medications: Linking Receptor Antagonism to Neuropsychological Functioning in First Episode Psychosis
Baitz, Heather A.
Thornton, Allen E.
Procyshyn, Ric M.
Smith, Geoffrey N.
MacEwan, G. William
Kopala, Lili C.
Barr, Alasdair M.
Lang, Donna J.
Honer, William G.
[J]. JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2012, 18 (04) : 717 - 727
[10] Cognitive reserve in neuropsychiatry
Barnett, J. H.
Salmond, C. H.
Jones, P. B.
Sahakian, B. J.
[J]. PSYCHOLOGICAL MEDICINE, 2006, 36 (08) : 1053 - 1064

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