Anti-Inflammatory Effect of Diclofenac Diethylammonium Gel on Acute Phase of Ligature Induced Periodontitis in Rats

被引：0

作者：

Botelho, Marco A. ^{[1
,3
]}

Paixao, Monica S. ^{[2
]}

Rachid, Italo ^{[3
]}

Bannet, Leonard Edward ^{[3
]}

Patrus, Ana Helena ^{[3
]}

Mattos, Thiago Borges ^{[4
]}

Queiroz, Dinalva ^{[5
]}

Ruela, Ronaldo ^{[5
]}

Costa, Jose M. C. ^{[6
]}

Quintans, Lucindo, Jr. ^{[7
]}

机构：

[1] IFCE, Inst Fed Educ Ciencia & Tecnol Ceara, BR-62700000 Caninde, CE, Brazil

[2] Univ Fed Sergipe, Dept Odontol, BR-49060100 Aracaju, SE, Brazil

[3] Univ Potiguar UNP, Programa Posgrad Odontol, BR-59056000 Natal, RN, Brazil

[4] Univ Sagrado Coracao, Programa Posgrad Odontol, BR-17011160 Bauru, SP, Brazil

[5] Conselho Nacl Desenvolvimento Cient Tecnol CNPq, BR-70740901 Brasilia, DF, Brazil

[6] Univ Fed Ceara, Dept Tecnol Alimentos, BR-60356000 Fortaleza, Ceara, Brazil

[7] Univ Fed Sergipe, Dept Fisiol, BR-49100001 Aracaju, SE, Brazil

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2010年 / 29卷 / 08期

关键词：

Diclofenac diethylammonium; Inflammation; Periodontitis; rats; ALVEOLAR BONE-RESORPTION; ESSENTIAL OIL MOUTHRINSE; LIPPIA-SIDOIDES; GINGIVITIS; CARVACROL; DELIVERY;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study aimed to evaluate the effect of a diclofenac diethylammonium gel 10 mg/g (DD) on acute phase of ligature induced periodontitis model in rats. Experimental Periodontitis Disease (EPD) was induced in 30 Wistar rats subjected to ligature placement on left molars. Animals were treated with (DD), immediately after (EPD) induction. Saline-based gel (SG) was utilized as negative control and DD gel 10 mg/g was the tested substance. Animals were randomly assigned into the groups. The periodontium and the surrounding gingiva were examined at histopathology, as well as the neutrophil influx into the gingiva was assayed using myeloperoxidase activity levels by ELISA method. DD treatment reduced tissue lesion at histopathology coupled to decreased myeloperoxidase activity production in gingival tissue when compared to the saline gel control group (p < 0.05). The DD gel was able to provide a significant myeloperoxidase decreasing in gingiva tissue confirming to be effective in reducing gingival inflammation in this model.

引用

页码：1371 / 1376

页数：6

共 17 条

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