Connective tissue growth factor (CTGF/CCN2) ELISA: a novel tool for monitoring fibrosis

被引：54

作者：

Dendooven, Amlie ^{[1
]}

Gerritsen, Karin G. ^{[1
,2
]}

Nguyen, Tri Q. ^{[1
]}

Kok, Robbert J. ^{[3
]}

Goldschmeding, Roel ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Pathol, NL-3584 CX Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Nephrol & Hypertens, NL-3584 CX Utrecht, Netherlands

[3] Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, Utrecht, Netherlands

来源：

BIOMARKERS | 2011年 / 16卷 / 04期

关键词：

Connective tissue growth factor; fibrosis; biomarker; sandwich ELISA; TYPE-1; DIABETIC-PATIENTS; FACTOR GENE-EXPRESSION; FACTOR CTGF; CCN FAMILY; SYSTEMIC-SCLEROSIS; EPITHELIAL-CELLS; FACTOR EXCRETION; ANGIOTENSIN-II; RENAL-DISEASE; HUMAN LIVER;

D O I：

10.3109/1354750X.2011.561366

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: Connective tissue growth factor (CTGF) has been identified as a key factor in the pathogenesis of diseases with significant fibrosis-related complications such as hepatitis, diabetes and renal transplantation. Increasing evidence shows that CTGF levels in plasma, serum and urine have promising biomarker applicability in these disorders. Objective: To present an overview of current knowledge on CTGF in various patient populations and the technical aspects of CTGF measurement by enzyme-linked immunosorbent assay (ELISA). Method: We performed a comprehensive literature search by using electronic bibliographic databases. Conclusion: CTGF is associated with disease severity parameters and outcome in fibrotic disease and may have diagnostic and prognostic values. However, CTGF ELISA needs standardization.

引用

页码：289 / 301

页数：13

共 89 条

[31] Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis [J].

Inoki, I ;

Shiomi, T ;

Hashimoto, G ;

Enomoto, H ;

Nakamura, H ;

Makino, K ;

Ikeda, E ;

Takata, S ;

Kobayashi, K ;

Okada, Y .

FASEB JOURNAL, 2001, 15 (14) :219-+

[32] Expression of connective tissue growth factor in human renal fibrosis [J].

Ito, Y ;

Aten, J ;

Bende, RJ ;

Oemar, BS ;

Rabelink, TJ ;

Weening, JJ ;

Goldschmeding, R .

KIDNEY INTERNATIONAL, 1998, 53 (04) :853-861

[33] Involvement of Connective Tissue Growth Factor in Human and Experimental Hypertensive Nephrosclerosis [J].

Ito, Yasuhiko ;

Aten, Jan ;

Nguyen, Tri Q. ;

Joles, Jaap A. ;

Matsuo, Seiichi ;

Weening, Jan J. ;

Goldschmeding, Roel .

NEPHRON EXPERIMENTAL NEPHROLOGY, 2011, 117 (01) :E9-E20

[34] Induction of connective tissue growth factor by angiotensin II - Integration of signaling pathways [J].

Iwanciw, D ;

Rehm, M ;

Porst, M ;

Goppelt-Struebe, M .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (10) :1782-1787

[35] Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes [J].

Jaffa, Ayad A. ;

Usinger, William R. ;

McHenry, M. Brent ;

Jaffa, Miran A. ;

Lipstiz, Stuart R. ;

Lackland, Daniel ;

Lopes-Virella, Maria ;

Luttrell, Louis M. ;

Wilson, Peter W. F. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (05) :1893-1900

[36] Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population [J].

Kawaguchi, Y. ;

Ota, Y. ;

Kawamoto, M. ;

Ito, I. ;

Tsuchiya, N. ;

Sugiura, T. ;

Katsumata, Y. ;

Soejima, M. ;

Sato, S. ;

Hasegawa, M. ;

Fujimoto, M. ;

Takehara, K. ;

Kuwana, M. ;

Yamanaka, H. ;

Hara, M. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (12) :1921-1924

[37] Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes [J].

Kemp, TJ ;

Aggeli, IK ;

Sugden, PH ;

Clerk, A .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2004, 37 (02) :603-606

[38] Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily [J].

Kim, HS ;

Nagalla, SR ;

Oh, Y ;

Wilson, E ;

Roberts, CT ;

Rosenfeld, RG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (24) :12981-12986

[39] Connective tissue growth factor and progressive fibrosis in biliary atresia [J].

Kobayashi, H ;

Hayashi, N ;

Hayashi, K ;

Yamataka, A ;

Lane, GJ ;

Miyano, T .

PEDIATRIC SURGERY INTERNATIONAL, 2005, 21 (01) :12-16

[40] Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure [J].

Koitabashi, Norimichi ;

Arai, Masashi ;

Niwano, Kazuo ;

Watanabe, Atai ;

Endoh, Michiko ;

Suguta, Masahiko ;

Yokoyama, Tomoyuki ;

Tada, Hiroshi ;

Toyama, Takuji ;

Adachi, Hitoshi ;

Naito, Shigeto ;

Oshima, Shigeru ;

Nishida, Takashi ;

Kubota, Satoshi ;

Takigawa, Masaharu ;

Kurabayashi, Masahiko .

EUROPEAN JOURNAL OF HEART FAILURE, 2008, 10 (04) :373-379

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