Connective tissue growth factor (CTGF/CCN2) ELISA: a novel tool for monitoring fibrosis

被引：54
作者：
Dendooven, Amlie [1 ]
Gerritsen, Karin G. [1 ,2 ]
Nguyen, Tri Q. [1 ]
Kok, Robbert J. [3 ]
Goldschmeding, Roel [1 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Pathol, NL-3584 CX Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Dept Nephrol & Hypertens, NL-3584 CX Utrecht, Netherlands
[3] Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, Utrecht, Netherlands
来源：
BIOMARKERS | 2011年 / 16卷 / 04期
关键词：
Connective tissue growth factor; fibrosis; biomarker; sandwich ELISA; TYPE-1; DIABETIC-PATIENTS; FACTOR GENE-EXPRESSION; FACTOR CTGF; CCN FAMILY; SYSTEMIC-SCLEROSIS; EPITHELIAL-CELLS; FACTOR EXCRETION; ANGIOTENSIN-II; RENAL-DISEASE; HUMAN LIVER;
D O I：
10.3109/1354750X.2011.561366
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: Connective tissue growth factor (CTGF) has been identified as a key factor in the pathogenesis of diseases with significant fibrosis-related complications such as hepatitis, diabetes and renal transplantation. Increasing evidence shows that CTGF levels in plasma, serum and urine have promising biomarker applicability in these disorders. Objective: To present an overview of current knowledge on CTGF in various patient populations and the technical aspects of CTGF measurement by enzyme-linked immunosorbent assay (ELISA). Method: We performed a comprehensive literature search by using electronic bibliographic databases. Conclusion: CTGF is associated with disease severity parameters and outcome in fibrotic disease and may have diagnostic and prognostic values. However, CTGF ELISA needs standardization.
引用
收藏
页码：289 / 301
页数：13
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