Function and evolution of RNA N6-methyladenosine modification

被引：103

作者：

Zhu, Zhi-Man ^{[1
]}

Huo, Fu-Chun ^{[1
]}

Pei, Dong-Sheng ^{[1
]}

机构：

[1] Xuzhou Med Univ, Dept Pathol, Xuzhou 221004, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2020年 / 16卷 / 11期

基金：

中国国家自然科学基金;

关键词：

m(6)A modification; methylation; RNA; function; SINGLE-NUCLEOTIDE-RESOLUTION; PRE-MESSENGER-RNA; M(6)A METHYLATION; CROSS-LINKING; N-6-METHYLADENOSINE; TRANSLATION; METTL3; STEM; ALKBH5; VIRUS;

D O I：

10.7150/ijbs.45231

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N6-methyladenosine (m(6)A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m6A modification is installed by RNA methyltransferases METTL3, METTL14 and WTAP (Writers), removed by the demethylases FTO and ALKBH5 (Erasers) and recognized by m(6)A binding proteins, such as YT521-B homology YTH domain-containing proteins (Readers). Accumulating evidence shows that m(6)A RNA methylation participates in almost all aspects of RNA processing, implying an association with important bioprocesses. In this review, we mainly summarize and discuss the functional relevance and importance of m(6)A modification in cellular processes.

引用

页码：1929 / 1940

页数：12

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