Use of a Tandem Prins/Friedel-Crafts Reaction in the Construction of the Indeno-Tetrahydropyridine Core of the Haouamine Alkaloids: Formal Synthesis of (-)-Haouamine A

被引:50
作者
Fenster, Erik [1 ]
Fehl, Charlie [1 ]
Aube, Jeffrey [1 ]
机构
[1] Univ Kansas, KU Chem Methodol & Lib Dev Ctr, Lawrence, KS 66047 USA
关键词
3-COMPONENT SYNTHESIS; ONE-POT; CYCLIZATION;
D O I
10.1021/ol200725m
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A tandem Prins/friedel-Crafts reaction useful for the construction of the indeno-tetrahydropyridine core of the haouamine alkaloids and a formal synthesis of (-)-haouamine A are described.
引用
收藏
页码:2614 / 2617
页数:4
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