Shape effect on non-covalent dimer stability using classic scaled particle theory

被引：7
作者：
Graziano, Giuseppe [1 ]
机构：
[1] Univ Sannio, Dept Sci & Technol, Via Francesco Sanctis Snc, I-82100 Benevento, Italy
来源：
CHEMICAL PHYSICS LETTERS | 2020年 / 743卷 / 743期
关键词：
CAVITY CREATION; WATER; DIMERIZATION; SOLVATION; ENERGY;
D O I：
10.1016/j.cplett.2020.137176
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The shape of two non-covalent dimers formed by different variants of the B1 domain of protein G plays an important role for their stability in water and aqueous solutions [Proc. Natl. Acad. Sci. U.S.A. 115 (2018) 10965]. I demonstrate how much the stabilization afforded by the decrease in solvent-excluded volume upon association depends on the shape of the dimers in water and aqueous sugar solutions, using classic scaled particle theory. There is a strong dependence upon the decrease in water accessible surface area associated with dimer formation, whose general significance deserves attention.
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页数：6
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