Hypotheses on the etiology of antineutrophil cytoplasmic autoantibody-associated vasculitis: The cause is hidden, but the result is known

被引：71

作者：

van Wijngaarden, Robert A. F. de Lind ^{[1
]}

van Rijn, Leendert ^{[1
]}

Hagen, E. Christiaan ^{[2
]}

Watts, Richard A. ^{[3
]}

Gregorini, Gina ^{[4
]}

Tervaert, Jan Willem Cohen ^{[5
]}

Mahr, Alfred D. ^{[6
]}

Niles, John L. ^{[7
]}

de Heer, Emile ^{[1
]}

Bruijn, Jan A. ^{[1
]}

Bajema, Ingeborg M. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Pathol, NL-2300 RC Leiden, Netherlands

[2] Meander Med Ctr, Dept Internal Med, Amersfoort, Netherlands

[3] Univ E Anglia, Sch Med Hlth Policy & Practice, Norwich NR4 7TJ, Norfolk, England

[4] Univ Brescia, Dept Nephrol, Spedali Civili, I-25121 Brescia, Italy

[5] Univ Hosp Maastricht, Dept Clin & Expt Immunol, Maastricht, Netherlands

[6] Hop Cochin, Dept Internal Med, F-75674 Paris, France

[7] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

来源：

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2008年 / 3卷 / 01期

关键词：

D O I：

10.2215/CJN.03550807

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The first description of what is now known as antineutrophil cytoplasmic autoantibody-associated necrotizing vasculitis appeared more than 140 yr ago. Since then, many aspects of the pathogenic pathway have been elucidated, indicating the involvement of antineutrophil cytoplasmic autoantibodies, but why antineutrophil cytoplasmic autoantibodies are produced in the first place remains unknown. Over the years, many hypotheses have emerged addressing the etiology of antineutrophil cytoplasmic antibody production, but no exclusive factor or set of factors can so far be held responsible. Herein is reviewed the most influential hypotheses regarding the causes of antineutrophil cytoplasmic antibody-associated vasculitis with the aim of placing in an epidemiologic background the different hypotheses that are centered on environmental and genetic influences.

引用

页码：237 / 252

页数：16

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